PMID: 15379655Sep 24, 2004Paper

SNP discovery and typing technologies for pharmacogenomics

Current Topics in Medicinal Chemistry
Richard M Twyman

Abstract

Genetic variation in the human genome occurs predominantly as single nucleotide polymorphisms (SNPs). Our DNA may contain as many as ten million SNPs, of which three million or more are likely to differ between any two unrelated individuals. These three million genetic differences make a significant contribution to the observed variation in complex human phenotypes, such as disease susceptibility and our responses to drugs or environmental chemicals. Large-scale association studies taking place throughout the drug development process can help to identify such differences and tailor drugs and dose regimens to particular genotype classes. The need for such large-scale studies has driven the development of high-throughout SNP discovery and typing technologies, which are the subject of this review.

Citations

Feb 22, 2007·Nucleic Acids Research·Luisa OrsiniHarri Savilahti
Aug 13, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Huntington F WillardGeoffrey S Ginsburg
Mar 8, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Gabriella SpinicciNicola Carboni
Feb 27, 2007·Journal of Immunological Methods·Arnold CatsburgPaul H M Savelkoul
Aug 17, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gyorgy Csako
Jun 28, 2005·Epilepsy & Behavior : E&B·Thomas N Ferraro, Russell J Buono
Aug 18, 2009·Biosensors & Bioelectronics·Wei Jie Qin, Lin Yue Lanry Yung
Jul 15, 2005·Expert Opinion on Pharmacotherapy·Werner Kalow
May 2, 2009·Expert Opinion on Pharmacotherapy·Stefano Fogli, Michele Caraglia
Mar 26, 2009·BioTechniques·Jian-Yong XuSong-Lin Chen
Dec 6, 2006·Chemical Communications : Chem Comm·Nina MoranJames H R Tucker
Mar 8, 2005·Organic & Biomolecular Chemistry·Shinsuke SandoYasuhiro Aoyama
Apr 4, 2008·Organic & Biomolecular Chemistry·Seergazhi G SrivatsanYitzhak Tor
Jul 18, 2008·Chemical Communications : Chem Comm·Pavol Cekan, Snorri Th Sigurdsson
Dec 31, 2008·Chemistry : a European Journal·Anton Granzhan, Marie-Paule Teulade-Fichou
Sep 24, 2010·Organic & Biomolecular Chemistry·Yun XieYitzhak Tor
Oct 19, 2005·Angewandte Chemie·Michael Strerath, Andreas Marx
Jan 20, 2006·Analytical and Bioanalytical Chemistry·Michael Y ShaSharron G Penn
Jan 17, 2012·Chemical Communications : Chem Comm·Jorge EscorihuelaÁngel Maquieira
Feb 10, 2011·Chemistry : a European Journal·Huaibin ZhangRalph G Nuzzo
Feb 16, 2011·Chembiochem : a European Journal of Chemical Biology·Haraldur GardarssonSnorri Th Sigurdsson
Nov 26, 2009·Journal of the American Chemical Society·Pavol Cekan, Snorri Th Sigurdsson

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