Abstract
The fields of pharmacogenetics and pharmacogenomics have become increasingly promising regarding the clinical application of genetic data to aid in prevention of adverse reactions. Specific screening tests can predict which animals express modified proteins or genetic sequences responsible for adverse effects associated with a drug. Among the genetic variations that have been investigated in dogs, the multidrug resistance gene (MDR) is the best studied. However, other genes such as CYP1A2 and CYP2B11 control the protein syntheses involved in the metabolism of many drugs. In the present study, the MDR-1, CYP1A2 and CYP2B11 genes were examined to identify SNP polymorphisms associated with these genes in the following four canine breeds: Uruguayan Cimarron, Border Collie, Labrador Retriever and German Shepherd. The results revealed that several SNPs of the CYP1A2 and CYP2B11 genes are potential targets for drug sensitivity investigations.
References
Apr 1, 1997·Toxicology and Applied Pharmacology·G R LankasD Umbenhauer
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jun 26, 1999·Gastroenterology·R J FontanaP B Watkins
Dec 14, 2001·AAPS PharmSci·L MancinelliW Sadée
Oct 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Richard A GrahamAndrew Parkinson
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mark W NeffNiels C Pedersen
Nov 27, 2004·Pharmacogenetics·Masashi MiseToshihiko Fujii
Mar 4, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D TenmizuH Kamimura
Dec 13, 2005·Nature·Kerstin Lindblad-TohEric S Lander
Apr 28, 2006·Archives of Toxicology·H Kamimura
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Nov 15, 2006·Journal of Clinical Pharmacology·Robert L WalskyR Scott Obach
Apr 1, 2007·Drug Metabolism Letters·Valerie J WhiterockMichael W Sinz
Dec 1, 2009·Archives of Biochemistry and Biophysics·Jyothi C TalakadJames R Halpert
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·M T BarattaC W Locuson
Jan 12, 2011·Journal of Veterinary Pharmacology and Therapeutics·J S Aretz, J Geyer
Apr 15, 2011·Journal of Veterinary Internal Medicine·L AlvesM Drögemüller
Jun 4, 2011·Genetics and Molecular Biology·Rosa GagliardiMaría Victoria Arruga
Nov 15, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Valerie J WhiterockMichael W Sinz
Sep 25, 2012·Journal of Veterinary Internal Medicine·K R MuñanaK L Mealey
May 15, 2013·Nucleic Acids Research·Hamish McWilliamRodrigo Lopez
Dec 5, 2013·Disease Markers·Keijiro MizukamiOsamu Yamato
Dec 18, 2013·The Veterinary Journal·Hirotaka TomiyasuHajime Tsujimoto
Citations
Dec 3, 2017·Journal of Veterinary Internal Medicine·M DunningS Fox
Sep 12, 2017·Journal of Veterinary Pharmacology and Therapeutics·K Kongara
Jun 20, 2018·Journal of Veterinary Pharmacology and Therapeutics·Marilyn N MartinezKatrina L Mealey