SNP rs10420324 in the AMPA receptor auxiliary subunit TARP γ-8 regulates the susceptibility to antisocial personality disorder.

Scientific Reports
Shi-Xiao PengYun Stone Shi

Abstract

In the brain, AMPA receptors mediate fast excitatory neurotransmission, the dysfunction of which leads to neuropsychiatric disorders. Synaptic function of AMPA receptors is tightly controlled by a protein group called transmembrane AMPAR regulatory proteins (TARPs). TARP γ-8 (also known as CACNG8) preferentially expresses in the hippocampus, cortex and subcortical regions that are critical for emotion generation indicating its association with psychiatric disorders. Here, we identified rs10420324 (T/G), a SNP located in the human CACNG8 gene, regulated reporter gene expression in vitro and TARP γ-8 expression in the human brain. A guanine at the locus (rs10420324G) suppressed transcription likely through modulation of a local G-quadruplex DNA structure. Consistent with these observations, the frequency of rs10420324G was higher in patients with anti-social personality disorder (ASPD) than in controls, indicating that rs10420324G in CACNG8 is more voluntary for ASPD. We then characterized the behavior of TARP γ-8 knockout and heterozygous mice and found that consistent with ASPD patients who often exhibit impulsivity, aggression, risk taking, irresponsibility and callousness, a decreased γ-8 expression in mice displayed similar ...Continue Reading

References

Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Aug 11, 1998·Nature Genetics·V A LettsW N Frankel
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
May 3, 2002·Molecular Psychiatry·R S Duman
Jun 8, 2002·Annual Review of Neuroscience·Roberto Malinow, Robert C Malenka
May 29, 2003·The Journal of Cell Biology·Susumu TomitaDavid S Bredt
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Oct 14, 2005·Nature Neuroscience·Nathalie RouachRoger A Nicoll
May 5, 2006·Brain : a Journal of Neurology·S F Cooke, T V P Bliss
Jun 3, 2008·Trends in Pharmacological Sciences·Aaron D Milstein, Roger A Nicoll
Feb 17, 2009·Neuron·Helmut W Kessels, Roberto Malinow
Dec 24, 2010·Nature·Laura BevilacquaDavid Goldman
Sep 29, 2011·The Journal of Physiology·Dan Yan, Susumu Tomita
Oct 14, 2011·Current Opinion in Neurobiology·Christoph Straub, Susumu Tomita
Oct 31, 2012·Personality Disorders·Donald R Lynam, David D Vachon
Dec 12, 2012·Trends in Neurosciences·Pierre-Eric Lutz, Brigitte L Kieffer
Nov 5, 2013·Neuron·Richard L Huganir, Roger A Nicoll
Aug 19, 2014·Current Topics in Behavioral Neurosciences·Christopher J Patrick
Jan 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Maya YamazakiRoger A Nicoll
Apr 22, 2015·Annual Review of Neuroscience·Lenora VolkRichard L Huganir
May 18, 2016·Current Topics in Behavioral Neurosciences·Julen Hernandez-LallementTobias Kalenscher
Jul 2, 2016·Science·Edward C TwomeyAlexander I Sobolevsky
Jan 4, 2017·Neuroscience and Biobehavioral Reviews·Julen Hernandez-LallementTobias Kalenscher
Aug 2, 2017·Trends in Biotechnology·Chun Kit Kwok, Catherine J Merrick
Mar 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Nengyin ShengRoger A Nicoll
Jul 6, 2018·Biosensors & Bioelectronics·László Kékedy-NagyElena E Ferapontova
Nov 13, 2018·Cell·Lowry A KirkbyVikaas S Sohal
Jan 8, 2019·Psychiatry Research·Märta WalliniusEva Billstedt

❮ Previous
Next ❯

Software Mentioned

Clampe10
ZhengHua
ARRIVE
ImageJ
SNPinfo
Statistical Product and Service Solutions ( SPSS )

Related Concepts

Related Feeds

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.