SNP rs356219 of the α-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population

Parkinsonism & Related Disorders
Fenghua PanXinsheng Ding

Abstract

Over the last decades, increasing knowledge about the genetic architecture of Parkinson's disease(PD) has provided novel insights into the pathogenesis of the disorder. Recently, several studies in different populations have found a strong association between idiopathic PD and the single-nucleotide polymorphism (SNP) rs356219, which is located in the 3'UTR of the SNCA gene. In this study, we aimed to verify these findings and to explore further the nature of the association in a subset of Chinese Han PD patients. Four hundred and three unrelated patients with sporadic PD and 315 healthy ethnically matched control subjects were recruited consecutively for the study. Patients and normal controls were genotyped for SNCA rs356219 variant by ligase detection reaction (LDR). A statistically significant difference was found in the frequencies of the single alleles of rs356219 (χ(2) = 12.986,P = 0.002) between PD patients and normal subjects. The distribution of A > G genotypes was different between patients and controls (χ(2) = 13.243, P < 0.001). The OR for subjects with the variant genotypes (AG and GG) was 1.88 (95%CI = 1.27-2.78, P = 0.001). The frequencies of the homozygous genotype for this variant was 42.2% (170 patients), whic...Continue Reading

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Citations

Aug 12, 2014·Neuroscience Letters·Gheona AltarescuDeborah Elstein
Jun 6, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nan-Nan LiRong Peng
Jul 9, 2013·Parkinsonism & Related Disorders·A EmelyanovS Pchelina
Aug 20, 2016·Journal of the Neurological Sciences·Lan ChengRong Peng
Jul 6, 2017·Frontiers in Aging Neuroscience·Clarissa L C CampêloRegina H Silva
Nov 10, 2018·Frontiers in Molecular Neuroscience·Yuan ZhangBeisha Tang
Aug 7, 2017·Parkinson's Disease·Clarissa Loureiro das Chagas Campêlo, Regina Helena Silva
Mar 6, 2018·Neurobiology of Aging·Roxana G BurciuDavid E Vaillancourt
Apr 19, 2021·Neuroscience Letters·Alma Cristina Salas-LealAda A Sandoval-Carrillo

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