SNP Variation in MicroRNA Biogenesis Pathway Genes as a New Innovation Strategy for Alzheimer Disease Diagnostics: A Study of 10 Candidate Genes in an Understudied Population From the Eastern Mediterranean

Alzheimer Disease and Associated Disorders
Şenay Görücü YilmazMehmet Ali Sungur

Abstract

Alzheimer disease (AD) is a common complex neurodegenerative disorder accounting for nearly 50% to 70% of dementias worldwide. Yet the current diagnostic options for AD are limited. New diagnostic innovation strategies focusing on novel molecules and pathways are sorely needed. In this connection, microRNAs (miRNAs) are conserved small noncoding RNAs that regulate posttranscriptional gene expression and are vital for neuronal development and its functional sustainability. Conceivably, biological pathways responsible for the biogenesis of miRNAs represent a veritable set of upstream candidate genes that can be potentially associated with the AD pathophysiology. Notably, whereas functional single-nucleotide polymorphisms (SNPs) in miRNA biogenesis pathway genes have been studied in other complex diseases, surprisingly, virtually no such study has been conducted on their relevance in AD. Moreover, novel diagnostics identified in easily accessible peripheral tissues such as the whole blood samples represent the initial entry or gateway points on the biomarker discovery critical path for AD. To the best of our knowledge, we report here the first association study of functional SNPs, as measured by real-time PCR in 10 "upstream" cand...Continue Reading

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Citations

Aug 9, 2016·Omics : a Journal of Integrative Biology·Şenay Görücü YılmazMehmet Ali Sungur
Mar 24, 2018·Epigenomics·Karin Hrovatin, Tanja Kunej
Aug 4, 2019·International Journal of Molecular Sciences·Eun Ju KoNam Keun Kim
Feb 4, 2021·Experimental and Molecular Pathology·Jéssica Vilarinho CardosoJamila Alessandra Perini

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