SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

Nature Genetics
Hiroyuki UnokiShiro Maeda

Abstract

We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 x 10(-12); OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 x 10(-9); OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 x 10(-13); OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36).

Associated Clinical Trials

References

Nov 4, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T LauritzenUNKNOWN Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care
Dec 20, 2000·The Journal of Clinical Investigation·M P LeeA P Feinberg
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M C CasimiroK Pfeifer
Aug 15, 2001·Journal of Human Genetics·Y OhnishiY Nakamura
Dec 10, 2003·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Torben JørgensenCharlotta Pisinger
Jan 22, 2005·Science·Stephen O'RahillyNicholas J Wareham
Mar 25, 2005·American Journal of Human Genetics·Janis E WiggintonGoncalo R Abecasis
Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Volker VallonFlorian Lang
Jan 18, 2006·Nature Genetics·Struan F A GrantKari Stefansson
Apr 27, 2007·Nature Genetics·Valgerdur SteinthorsdottirKari Stefansson
Apr 28, 2007·Science·UNKNOWN Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical RShaun Purcell
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart

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Citations

Feb 18, 2010·JAMA : the Journal of the American Medical Association·Nina P PaynterPaul M Ridker
Nov 3, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Caroline KettererHarald Staiger
Apr 20, 2010·Pflügers Archiv : European journal of physiology·Snezana MaljevicHolger Lerche
Oct 28, 2010·Pflügers Archiv : European journal of physiology·Henning FröhlichFlorian Lang
Jun 8, 2011·Human Genetics·Mary E Travers, Mark I McCarthy
Mar 28, 2009·Current Diabetes Reports·Mark I McCarthy, Eleftheria Zeggini
Sep 8, 2010·Current Diabetes Reports·Richard M Watanabe
Dec 6, 2011·Current Diabetes Reports·Angharad R Morgan
Sep 21, 2012·Current Diabetes Reports·Yoon Shin ChoChu Won Nho
Oct 16, 2013·Current Diabetes Reports·Hui Jin Ng, Anna L Gloyn
Sep 29, 2012·Molecular Diagnosis & Therapy·Gaia Chiara Mannino, Giorgio Sesti
May 22, 2010·The British Journal of Nutrition·Clive J Petry
Jan 6, 2010·Expert Reviews in Molecular Medicine·Helen E ParkerFiona M Gribble
Feb 27, 2010·Expert Reviews in Molecular Medicine·Karani S Vimaleswaran, Ruth J F Loos
Apr 1, 2010·Journal of Developmental Origins of Health and Disease·B M ShieldsA T Hattersley
Feb 2, 2012·European Journal of Human Genetics : EJHG·Jennifer AsimitEleftheria Zeggini
May 24, 2012·European Journal of Human Genetics : EJHG·Rick Twee-Hee OngYik-Ying Teo
Jan 23, 2009·Journal of Human Genetics·Yusuke Nakamura
Nov 26, 2010·Journal of Human Genetics·Asako AokiToshihiro Tanaka
Mar 20, 2010·Journal of Human Genetics·Chee Seng KuKee Seng Chia
Nov 25, 2011·Journal of Human Genetics·Kurt A LangbergUNKNOWN American Diabetes Association GENNID Study Group
Sep 9, 2011·Journal of Human Genetics·Kazuhiko NakabayashiSenji Shirasawa

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