SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan

Toxicology and Applied Pharmacology
Ling-I HsuChien-Jen Chen

Abstract

A hospital-based case-control study was conducted near a former black-foot disease (BFD)-endemic area in southwestern Taiwan to examine the possible risk factors and genetic susceptibility for urinary transitional cell carcinoma (TCC). A total of 221 patients with pathologically confirmed TCC and 223 age-sex-matched control subjects from urology outpatient clinics were recruited between 1998 and 2002. The results showed that residency in the BFD area and consumption of well water for more than 10 years was a strong factor on urinary cancer risk (odds ratio [OR],8.16, 95% confidence interval [CI],3.34-19.90, p<0.0001). Dose response relationship between average arsenic concentration in well water and TCC risk was also observed. Cigarette smoking played a relatively minor role in urinary carcinogenesis in this study. The GSTP1 Ile105Val A-->G polymorphism was significantly associated with cancer risk (A/G+G/G: OR=0.60, 95%CI=0.39-0.94, p=0.02), and the effect of Val105 allele was largely confined to the subjects diagnosed earlier than 55 years old (A/G+G/G: OR,0.29; 95% CI, 0.09-0.87, p=0.03). The results suggest that GSTP1 is a candidate for susceptibility locus and Ile105 allele may predispose individuals to early-onset urinary...Continue Reading

Citations

Jul 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan-Zhong FengDao-Lin Xie
Mar 19, 2013·World Journal of Surgical Oncology·Yeqing MaoLiping Xie
Sep 29, 2011·Human Genetics·Margaret R KaragasKarl T Kelsey
Mar 14, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhenlong WangZiming Wang
May 29, 2014·International Journal of Environmental Research and Public Health·Chi-Ting ChiangTsun-Kuo Chang
Mar 13, 2016·Environmental Toxicology and Pharmacology·Dilek Kaya-AkyüzlüTülin Söylemezoğlu
May 4, 2013·Environmental and Molecular Mutagenesis·Jorge G Muñiz OrtizAndrew D Kligerman
Apr 25, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Zhe ZhangChui-Ze Kong
May 3, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fei ZhangHai-Tao Liu
Apr 16, 2013·International Journal of Environmental Research and Public Health·Francesca FaitaMaria Grazia Andreassi
Jul 10, 2019·International Journal of Colorectal Disease·Vittorio BranchiSebastian Schölch
Aug 11, 2020·Biological Trace Element Research·Baiming JinKewei Wang
Jul 29, 2017·Journal of the Chinese Medical Association : JCMA·Cheng-Huang ShenGuang-Dar Juang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.