SNR enhancement in brillouin microspectroscopy using spectrum reconstruction

Biomedical Optics Express
YuChen XiangPeter Török

Abstract

Brillouin spectroscopy can suffer from low signal-to-noise ratios (SNRs). Such low SNRs can render common data analysis protocols unreliable, especially for SNRs below ∼10. In this work we exploit two denoising algorithms, namely maximum entropy reconstruction (MER) and wavelet analysis (WA), to improve the accuracy and precision in determination of Brillouin shifts and linewidth. Algorithm performance is quantified using Monte-Carlo simulations and benchmarked against the Cramér-Rao lower bound. Superior estimation results are demonstrated even at low SNRs (≥ 1). Denoising is furthermore applied to experimental Brillouin spectra of distilled water at room temperature, allowing the speed of sound in water to be extracted. Experimental and theoretical values were found to be consistent to within ±1% at unity SNR.

References

Sep 19, 1998·Journal of Magnetic Resonance·K B LiJ C Hoch
Aug 15, 1986·Physical Review. B, Condensed Matter·S A LeeR C Hanson
Dec 9, 2003·Applied Optics·Jianfeng XuDahe Liu
Jan 30, 2004·Biophysical Journal·Raimund J OberE Sally Ward
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sripad RamRaimund J Ober
Aug 10, 2006·Nature Methods·Michael J RustXiaowei Zhuang
Aug 12, 2006·Science·Eric BetzigHarald F Hess
Sep 19, 2006·Biophysical Journal·Samuel T HessMichael D Mason
Sep 6, 2008·Optics Express·Andrew J BerglundJ Alexander Liddle
Dec 9, 2007·Nature Photonics·Giuliano Scarcelli, Seok Hyun Yun
Apr 7, 2010·Nature Methods·Carlas S SmithKeith A Lidke
Nov 28, 2013·Annual Review of Physical Chemistry·Alexander R Small, Raghuveer Parthasarathy
Mar 1, 2014·Nature Methods·Alex Small, Shane Stahlheber
Jan 23, 2015·JAMA Ophthalmology·Giuliano ScarcelliSeok Hyun Yun
Nov 13, 2015·Journal of the Royal Society, Interface·Giuseppe AntonacciPeter Török
Dec 23, 2015·Scientific Reports·Charles W BallmannVladislav V Yakovlev
Apr 7, 2016·Faraday Discussions·Guillaume LepertCarl Paterson
Nov 1, 2016·IEEE Access : Practical Innovations, Open Solutions·Madhur SrivastavaJack H Freed
Feb 7, 2018·Optics Express·Zachary CokerVladislav V Yakovlev
Apr 21, 2018·Biomedical Optics Express·Silvia ColabreseAlessio Del Bue
May 2, 2018·Applied Physics Letters·Eitan Edrei, Giuliano Scarcelli
Mar 7, 2019·Light, Science & Applications·Sara MattanaSilvia Caponi
Apr 18, 2019·Scientific Reports·Peter Török, Matthew R Foreman
Sep 25, 2019·Nature Methods·Robert PrevedelGiuseppe Antonacci

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Citations

May 28, 2020·Biophysics Reviews·Giuseppe AntonacciGiuliano Scarcelli
Dec 8, 2020·Biomedical Optics Express·YuChen XiangIrina V Kabakova
Mar 7, 2021·Journal of Biophotonics·YuChen XiangPeter Török

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Software Mentioned

Matlab
Matlab Wavelet Analyzer

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