Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates.

Blood
Chang Z ChunRamani Ramchandran

Abstract

In vertebrates, molecular mechanisms dictate angioblasts' migration and subsequent differentiation into arteries and veins. In this study, we used a microarray screen to identify a novel member of the sucrose nonfermenting related kinase (snrk-1) family of serine/threonine kinases expressed specifically in the embryonic zebrafish vasculature and investigated its function in vivo. Using gain- and loss-of-function studies in vivo, we show that Snrk-1 plays an essential role in the migration, maintenance, and differentiation of angioblasts. The kinase function of Snrk-1 is critical for migration and maintenance, but not for the differentiation of angioblasts. In vitro, snrk-1 knockdown endothelial cells show only defects in migration. The snrk-1 gene acts downstream or parallel to notch and upstream of gridlock during artery-vein specification, and the human gene compensates for zebrafish snrk-1 knockdown, suggesting evolutionary conservation of function.

References

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Citations

Aug 10, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amy K RinesHossein Ardehali
Apr 16, 2009·Current Opinion in Hematology·Eileen Boye, Bjorn R Olsen
Apr 27, 2011·Familial Cancer·Lina Udd, Tomi P Mäkelä
Feb 17, 2009·Developmental Cell·L-K Phng, Holger Gerhardt
Mar 17, 2009·Circulation Research·Matthew R Swift, Brant M Weinstein
Dec 16, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Qiulun LuMing-Hui Zou
Oct 27, 2016·Circulation. Cardiovascular Genetics·Stephanie M CossetteRamani Ramchandran
Nov 14, 2019·Journal of the American Heart Association·Karthikeyan ThirugnanamRamani Ramchandran
Jun 15, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Benjamin J HoldenTimothy J A Chico
Dec 17, 2014·Biology Open·Stephanie M CossetteRamani Ramchandran

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