SnRK1 from Arabidopsis thaliana is an atypical AMPK

The Plant Journal : for Cell and Molecular Biology
Shane EmanuelleDavid I Stapleton

Abstract

SNF1-related protein kinase 1 (SnRK1) is the plant orthologue of the evolutionarily-conserved SNF1/AMPK/SnRK1 protein kinase family that contributes to cellular energy homeostasis. Functional as heterotrimers, family members comprise a catalytic α subunit and non-catalytic β and γ subunits; multiple isoforms of each subunit type exist, giving rise to various isoenzymes. The Arabidopsis thaliana genome contains homologues of each subunit type, and, in addition, two atypical subunits, β(3) and βγ, with unique domain architecture, that are found only amongst plants, suggesting atypical heterotrimers. The AtSnRK1 subunit structure was determined using recombinant protein expression and endogenous co-immunoprecipitation, and six unique isoenzyme combinations were identified. Each heterotrimeric isoenzyme comprises a catalytic α subunit together with the unique βγ subunit and one of three non-catalytic β subunits: β(1), β(2) or the plant-specific β(3) isoform. Thus, the AtSnRK1 heterotrimers contain the atypical βγ subunit rather than a conventional γ subunit. Mammalian AMPK heterotrimers are phosphorylated on the T-loop (pThr175/176) within both catalytic a subunits. However, AtSnRK1 is insensitive to AMP and ADP, and is resistant t...Continue Reading

References

Dec 5, 1993·Journal of Molecular Biology·A Sali, T L Blundell
Jul 27, 1999·The Plant Journal : for Cell and Molecular Biology·J P BoulyM Thomas
Sep 16, 2000·The EMBO Journal·M C Schmidt, R R McCartney
May 16, 2003·Current Biology : CB·Galina PolekhinaDavid Stapleton
Dec 24, 2003·Protein Science : a Publication of the Protein Society·Julian AdamsBruce E Kemp
Feb 12, 2004·The Plant Journal : for Cell and Molecular Biology·Anna KulmaCarol MacKintosh
Apr 2, 2004·The EMBO Journal·Mattias ThelanderHans Ronne
Feb 8, 2005·The Journal of Biological Chemistry·Tristan J IseliDavid Stapleton
Oct 12, 2005·Structure·Galina PolekhinaMichael W Parker
Dec 7, 2006·The Biochemical Journal·Matthew J SandersDavid Carling
Dec 15, 2006·Trends in Plant Science·Cécile Polge, Martine Thomas
Jul 31, 2007·Plant, Cell & Environment·Alison M Smith, Mark Stitt
Aug 23, 2007·Nature Reviews. Molecular Cell Biology·D Grahame Hardie
Sep 11, 2007·The Plant Cell·Michèle PierreThierry Meinnel
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Kristina Hedbacker, Marian Carlson
Aug 15, 2008·Trends in Plant Science·Elena Baena-González, Jen Sheen
Mar 24, 2009·The Plant Journal : for Cell and Molecular Biology·Mathieu JossierMartine Thomas
May 20, 2009·FEBS Letters·Cristina López-PazVictoria Lumbreras
Aug 18, 2009·The FEBS Journal·Camilla ChristiansenBirte Svensson
Jul 20, 2010·FEBS Letters·Ann KoayPaul R Gooley
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jonathan S OakhillBruce E Kemp
Mar 15, 2011·Nature·Bing XiaoSteven J Gamblin
Jun 18, 2011·Science·Jonathan S OakhillBruce E Kemp
Jan 31, 2012·Trends in Endocrinology and Metabolism : TEM·Jonathan S OakhillBruce E Kemp
Jul 10, 2012·Biochemical and Biophysical Research Communications·Kimiko ChaenMakoto Kimura
Apr 5, 2013·The Plant Journal : for Cell and Molecular Biology·Matthew RamonFilip Rolland
Dec 20, 2013·Nature Communications·Bing XiaoSteven J Gamblin

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Citations

Aug 22, 2015·International Journal of Molecular Sciences·Adam BarradaBenoît Menand
Feb 24, 2016·Acta Pharmaceutica Sinica. B·David Grahame Hardie
Dec 15, 2015·The Plant Journal : for Cell and Molecular Biology·Pierre CrozetElena Baena-González
Sep 12, 2015·The Plant Journal : for Cell and Molecular Biology·Juanying YePingli Lu
Feb 26, 2016·Annual Review of Plant Biology·Thomas DobrenelChristian Meyer
May 8, 2016·Cellular and Molecular Life Sciences : CMLS·Štefan Janeček, Marek Gabriško
Jun 9, 2016·Journal of Experimental Botany·Valentin RoustanWolfram Weckwerth
Jul 17, 2016·Current Opinion in Plant Biology·Lei Li, Jen Sheen
Aug 18, 2016·Journal of Experimental Botany·Juanying YeHong Ma
Feb 24, 2018·Journal of Experimental Botany·Tamar Avin-WittenbergHenri Batoko
Feb 7, 2018·The Plant Journal : for Cell and Molecular Biology·Muhammed Jamsheer KAshverya Laxmi
Feb 22, 2018·Antioxidants & Redox Signaling·Karl-Josef DietzThorsten Seidel
Jul 7, 2018·PloS One·Yongzhong Zhang, Binquan Huang
May 17, 2018·Physiologia Plantarum·Esther Zúñiga-SánchezEleazar Martínez-Barajas
Jul 14, 2018·The Plant Journal : for Cell and Molecular Biology·Ana Ruiz-GayossoPatricia Coello
Mar 3, 2018·Scientific Reports·Osvaldo FilipeMonica Höfte
Feb 23, 2019·Journal of Experimental Botany·Leonor MargalhaElena Baena-González
Mar 15, 2019·Journal of Experimental Botany·Muhammed Jamsheer KAshverya Laxmi
May 24, 2019·The FEBS Journal·Aaron N BrunsDavid M Bisaro
Aug 8, 2017·PloS One·Junmarie Soto-Burgos, Diane C Bassham
Sep 2, 2017·Journal of Experimental Botany·Marie-Paule RaveneauDavid Macherel
Dec 5, 2018·Plant Molecular Biology·Judith Van DingenenDirk Inzé
Sep 10, 2020·Frontiers in Cell and Developmental Biology·Abitha SukumaranBiplab Dasgupta
Feb 7, 2019·Frontiers in Plant Science·Henry Christopher Janse van RensburgSantiago Signorelli
Jun 11, 2020·Biomolecules·Riccardo MilanesiFarida Tripodi
Jul 26, 2017·Frontiers in Plant Science·Liang ChenQin-Fang Chen
Jan 2, 2021·Biochemical and Biophysical Research Communications·Shoko MatsuokaTaishi Umezawa
Nov 17, 2019·The New Phytologist·Hsing-Yi ChoPierdomenico Perata
Feb 13, 2018·Biochemical and Biophysical Research Communications·Shane EmanuelleMatthew S Gentry
Mar 12, 2021·Journal of Experimental Botany·Muhammed Jamsheer KVibha Srivastava

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