SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting.

Seminars in Cell & Developmental Biology
Jan R T van WeeringPeter J Cullen

Abstract

The endocytic network is morphologically characterized by a wide variety of membrane bound compartments that are able to undergo dynamic re-modeling through tubular and vesicular structures. The precise molecular mechanisms governing such re-modeling, and the events that co-ordinated this with the major role of endosomes, cargo sorting, remain unclear. That said, recent work on a protein family of sorting nexins (SNX) - especially a subfamily of SNX that contain a BAR domain (SNX-BARs) - has begun to shed some much needed light on these issues and in particular the process of tubular-based endosomal sorting. SNX-BARs are evolutionary conserved in endosomal protein complexes such as retromer, where they co-ordinate membrane deformation with cargo selection. Furthermore a central theme emerges of SNX-BARs linking the forming membrane carrier to cytoskeletal elements for transport through motor proteins such as dynein. By studying these SNX-BARs, we are gaining an increasingly detailed appreciation of the mechanistic basis of endosomal sorting and how this highly dynamic process functions in health and disease.

References

Sep 1, 1996·Nature Genetics·D SakamuroG C Prendergast
Aug 12, 1998·The Journal of Cell Biology·M N SeamanS D Emr
Nov 4, 2000·Biochemical and Biophysical Research Communications·A J Edgar, J M Polak
Sep 7, 2002·Science·Balraj DorayStuart Kornfeld
Oct 22, 2002·Molecular Biology of the Cell·Dana Gilbert SchwarzTerry Magnuson
Apr 2, 2003·Journal of Cell Science·Corinne LeprinceJacques Camonis
Apr 16, 2003·Traffic·Mark A Lemmon
Sep 4, 2003·The Journal of Biological Chemistry·Richard Lundmark, Sven R Carlsson
Dec 3, 2003·Science·Brian J PeterHarvey T McMahon
Mar 27, 2004·Current Biology : CB·Joshua Zimmerberg, Stuart McLaughlin
Apr 14, 2004·The Journal of Cell Biology·Matthew N J Seaman
Apr 14, 2004·The Journal of Cell Biology·Cecilia N ArighiJuan S Bonifacino
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Trina A Schroer
Feb 8, 2005·Trends in Cell Biology·Matthew N J Seaman
Feb 11, 2005·Molecular Biology of the Cell·Fabienne SouletSandra L Schmid
Sep 3, 2005·FEBS Letters·Lee Yeow-FongEd Manser
Sep 6, 2005·Trends in Cell Biology·Jez G Carlton, Peter J Cullen
Oct 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Courtney T GriffinTerry Magnuson
Dec 2, 2005·Nature·Harvey T McMahon, Jennifer L Gallop
Dec 2, 2005·Nature·Rudy Behnia, Sean Munro
Jun 10, 2006·The EMBO Journal·Jennifer L GallopHarvey T McMahon
Jun 20, 2006·Biochimica Et Biophysica Acta·Li-Fong Seet, Wanjin Hong
Oct 13, 2006·Molecular and Cellular Endocrinology·Cheryl A NechamenJames A Dias
Nov 8, 2006·Biochemistry·Sárka MálkováMark L Schlossman
Dec 2, 2006·Nature Reviews. Molecular Cell Biology·Thierry Soldati, Manfred Schliwa
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karen BadourKatherine A Siminovitch
May 5, 2007·Annual Review of Biophysics and Biomolecular Structure·Thomas D Pollard
May 9, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Marcel Verges
Jun 7, 2007·Journal of Cell Science·Vincent PopoffLudger Johannes

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Citations

Apr 30, 2014·WormBook : the Online Review of C. Elegans Biology·Ken SatoBarth D Grant
Nov 23, 2013·Trends in Plant Science·David G Robinson, Peter Pimpl
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Natasha K HussainRichard L Huganir
Aug 29, 2014·Molecular Biology of the Cell·Georg H H BornerMargaret S Robinson
Mar 17, 2011·The Plant Cell·David G RobinsonJirí Friml
Sep 22, 2011·The Plant Cell·David ScheuringKarin Schumacher
Jun 22, 2012·Molecular Biology of the Cell·Timothy S GomezDaniel D Billadeau
Jun 22, 2012·PloS One·Véronique PonsJean Gruenberg
Oct 3, 2013·PloS One·Michèle LefebvreGilles Merlin
Mar 27, 2012·Protoplasma·York-Dieter StierhofDavid G Robinson
Jan 1, 2013·Cell Regeneration·Leilei ZhangDuanqing Pei
Nov 23, 2011·The Journal of Cell Biology·Lei WenWen-Cheng Xiong
Oct 13, 2010·The Journal of Cell Biology·Shin-ichiro YoshimuraFrancis A Barr
Jan 14, 2016·Nature·Tamas Balla
Feb 19, 2013·Journal of Proteomics·Bruno CatimelAntony W Burgess
Apr 17, 2012·Trends in Plant Science·David G RobinsonCorrado Viotti
Jan 28, 2012·Biochimica Et Biophysica Acta·Peter Mayinger
Apr 7, 2011·Current Opinion in Cell Biology·Kirsten SandvigBo van Deurs
Mar 1, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Makoto OkanoMotoyuki Itoh
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Oscar Diaz-HortaMustafa Tekin
Jul 25, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kay O SchinkHarald Stenmark
Oct 7, 2011·Traffic·Jan R T van WeeringPeter J Cullen
Sep 1, 2011·The EMBO Journal·Britta QualmannMichael Manfred Kessels
Oct 23, 2012·The EMBO Journal·Jan R T van WeeringPeter J Cullen
Jul 27, 2011·Biochemical Society Transactions·Peter J Cullen
Jan 27, 2015·Biochemical Society Transactions·Matthew Gallon, Peter J Cullen
Sep 23, 2011·Biochemical Society Transactions·Sylvie D Hunt, David J Stephens
Apr 9, 2015·Molecular Biology of the Cell·Varsha SinghMark Donowitz
Apr 23, 2013·Developmental Cell·Yue SunRichard A Anderson
Apr 29, 2014·Seminars in Cell & Developmental Biology·Lei Lu, Wanjin Hong
Apr 8, 2014·Seminars in Cell & Developmental Biology·Markus Kerr, Rohan D Teasdale
Sep 5, 2014·Protoplasma·Delphine GendreRishikesh P Bhalerao
Jul 18, 2014·PloS One·Anastasia V ShindyapinaYuri L Dorokhov
Jun 5, 2016·Journal of Experimental Botany·David G Robinson, Jean-Marc Neuhaus
May 9, 2012·PloS One·Yuri L DorokhovYuri Y Gleba

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