SNX10 and PTGDS are associated with the progression and prognosis of cervical squamous cell carcinoma.

BMC Cancer
Pinping JiangShilong Fu

Abstract

Cervical cancer (CC) is the primary cause of death in women. This study sought to investigate the potential mechanism and prognostic genes of CC. We downloaded four gene expression profiles from GEO. The RRA method was used to integrate and screen differentially expressed genes (DEGs) between CC and normal samples. Functional analysis was performed by clusterprofiler. We built PPI network by Search Tool for the Retrieval of Interacting Genes Database (STRING) and selected hub modules via Molecular COmplex Detection (MCODE). CMap database was used to find molecules with therapeutic potential for CC. The hub genes were validated in GEO datasets, Gene Expession Profiling Interactive Analysis (GEPIA), immunohistochemistry, Cox regression analysis, TCGA methylation analysis and ONCOMINE were carried out. ROC curve analysis and GSEA were also performed to describe the prognostic significance of hub genes. Functional analysis revealed that 147 DEGs were significantly enriched in binding, cell proliferation, transcriptional activity and cell cycle regulation. PPI network screened 30 hub genes, with CDK1 having the strongest connectivity with CC. Cmap showed that apigenin, thioguanine and trichostatin A might be used to treat CC(P < 0.0...Continue Reading

References

Jan 10, 2003·Nucleic Acids Research·Christian von MeringBerend Snel
Dec 23, 2006·Nature Reviews. Cancer·Justin Lamb
Mar 16, 2007·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Jul 24, 2007·Bioinformatics·Aravind SubramanianJill P Mesirov
Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J Y SongK W Lee
Dec 17, 2008·Cancer Treatment Reviews·Margherita NanniniGuido Biasco
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Dec 4, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·W Patricia BandettiniAndrew E Arai
Jun 15, 2014·The Oncologist·Pashna N MunshiJoseph R Bertino
Dec 3, 2014·Gynecologic Oncology·Roma MaguireCatherine Paterson
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 13, 2015·Molecular Oncology·Monika PiweckaJan Barciszewski
Jun 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Johan A den BoonPaul Ahlquist
Jul 1, 2015·Cancer Letters·Josef Ehling, Frank Tacke
Nov 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Beibei XieHaiyan Zhang
Feb 26, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·K BednarekM Jarmuz-Szymczak
Feb 27, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Debmalya RoyLi Sun
Apr 7, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nancy Cervantes-AnayaSaúl Villa-Treviño
May 23, 2017·Theranostics·Helen HaNouri Neamati
May 24, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chunjie XuQing Xu
Aug 18, 2017·International Journal of Molecular Sciences·Marnie NewellCatherine J Field

❮ Previous
Next ❯

Software Mentioned

GEPIA
Cytoscape
R package
clusterprofiler
Bioconductor
ONCOMINE
RRA
limma
limma R
Search Tool for the Retrieval of Interacting Database ( STRING )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.