PMID: 7546360Jan 1, 1995Paper

So-called intracranial germ cell tumours: are they really of germ cell origin?

British Journal of Neurosurgery
K Sano

Abstract

We have studied 139 cases of intracranial germ cell tumours up to the beginning of 1993, 63.3% of which showed monotypic histological patterns and 36.7% were shown to be mixed tumours. All these cases underwent surgery followed by radiation and/or chemotherapy. All cases of choriocarcinoma died within 2 years. Cases of yolk sac tumour (endodermal sinus tumour) and embryonal carcinoma also showed poor results. Mature teratoma had a 5-year survival rate (5 YSR) and 10-year survival rate (10 YSR) of 92.9% each. Immature teratoma and malignant teratoma showed a 5-YSR and 10-YSR of 75.0% each. Germinoma showed a 5-YSR of 94.7% and a 10-YSR of 91.2%. All these results may bring into question the validity of the germ cell theory, since germinoma, which should be the most undifferentiated according to the theory, was the most benign and choriocarcinoma and yolk sac tumour (endodermal sinus tumour) which should be the most differentiated, were the most malignant in the follow-up study. Therefore, germ cell tumours may not originate from one single type of cells (primordial germs cells), except for germinoma. The embryonic cells of various stages of embryogenesis may perhaps be misplaced in the bilaminar embryonic disc and become involve...Continue Reading

Citations

Sep 24, 1998·Journal of Pineal Research·N GrimoldiR Villani
Nov 17, 1998·Journal of Neurosurgery·Y SawamuraH Shirato
Feb 9, 1999·Journal of Neurosurgery·K Sano
Jul 2, 2008·Journal of Neurosurgery·Yuuta KamoshimaKazuhiko Sugiyama
May 24, 2011·World Neurosurgery·Nobuhito Saito
Jul 22, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Eun Soo KimHye-Rim Park
Mar 15, 2006·International Journal of Radiation Oncology, Biology, Physics·Lucie Lafay-CousinEric Bouffet
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·P N PlowmanD Doughty
Dec 26, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kyu-Won ShimJoong-Uhn Choi
Sep 21, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jie TangJunting Zhang
Sep 26, 2009·Journal of Pediatric Hematology/oncology·Kanyalakshmi AyyanarMark W Kieran
Jul 24, 2010·Virchows Archiv : an International Journal of Pathology·Dakeun Lee, Yeon-Lim Suh
Feb 3, 2011·Brain Tumor Pathology·Manoj BoharaKazunori Arita
Sep 8, 2010·Southern Medical Journal·Nandakumar SrinivasanAlok Oswal
Nov 1, 2005·Arquivos de neuro-psiquiatria·Patrícia Imperatriz Porto RondinelliLuís Fernando Lopes
Jul 12, 2018·Journal of Surgical Case Reports·Sami KhairyAbdullah Alobaid

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