So similar and so different: Circulating androgens and androgen origin in bulimic women

The Journal of Steroid Biochemistry and Molecular Biology
Sabine NaessénKjell A M Carlström

Abstract

Hyper androgen state frequently can be diagnosed in bulimic women. Eating disorder not otherwise specified (EDNOS) recognized as a less severe form of bulimia nervosa (BN). The objective of the study was to determine whether androgen levels and androgen origin differs in bulimic women compared to control subjects. Forty-six women with bulimia nervosa (BN), 31 with eating disorder not otherwise specified, purging type (EDNOS P) and 56 matched healthy controls were studied with respect to serum testosterone (T), 5alpha-dihydrotestosterone (DHT), sex hormone-binding globulin (SHBG), deyhydroepiahndrosterone sulfate (DHEAS) and luteinizing hormone (LH) and to ovarian morphology. Despite all groups had almost identical androgen and SHBG levels; there were differences in the origin of circulating T and DHT. Correlation analysis suggest major differences in the formation of circulating testosterone (T) and 5α-dihydrotestosterone (DHT) with BN being more like the control subjects with peripheral formation from 4-androsterne-3,17-dione (A-4), dehydroepiandrosterone sulfate (DHEAS) and also from T. While in EDNOS group a possible direct ovarian T secretion and a DHEAS modulating action of androgens on pituitary gonadotropin secretion is ...Continue Reading

References

Jan 1, 1979·Acta Endocrinologica·E VanlucheneD V Vandekerckhove
Sep 19, 1992·Lancet·S E McCluskeyJ M Pearce
Aug 1, 1980·The Journal of Clinical Endocrinology and Metabolism·B V Zumoff, H L Bradlow
Mar 1, 1981·Clinics in Endocrinology and Metabolism·R G CrillyB E Nordin
Mar 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·C G Fairburn, P J Cooper
Jun 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S JahanfarT V Nguyent
Oct 1, 1995·Clinical Endocrinology·F J RaphaelJ H Lacey
Nov 1, 1994·Acta Psychiatrica Scandinavica·C SundbladE Eriksson
Mar 16, 1996·Lancet·S J ClelandJ M Connell
Oct 16, 2001·International Review of Neurobiology·S H Mellon, H Vaudry
May 16, 2002·Fertility and Sterility·John F MorganJ Hubert Lacey
Jan 22, 2003·Seminars in Reproductive Medicine·Christopher R McCartneyJohn C Marshall
Feb 8, 2003·Lancet·Christopher G Fairburn, Paul J Harrison
May 29, 2003·The International Journal of Eating Disorders·Francisco J VazEva M Peñas-Lledó
Dec 31, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A Lindén HirschbergJ Holtet
Sep 9, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M ReschP Haász
Nov 19, 2005·The Journal of Endocrinology·F LabrieC Labrie
Jul 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sabine NaessénAngelica Lindén Hirschberg
Mar 7, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Asa LindholmInger Sundström-Poromaa
Apr 25, 2008·The International Journal of Eating Disorders·John MorganGerard Conway
Nov 26, 2009·Lancet·Janet TreasureNancy Zucker
Jan 5, 2011·Molecular and Cellular Endocrinology·Christian G ZieglerStefan R Bornstein
Mar 4, 2011·The American Journal of Clinical Nutrition·Wassif S WassifNorman F Taylor
Oct 29, 2011·The Journal of Sexual Medicine·Abdulmaged M TraishAndre T Guay
Apr 8, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Luboslav StárkaMartin Hill
Oct 30, 2016·European Eating Disorders Review : the Journal of the Eating Disorders Association·Alessio Maria MonteleoneMario Maj
Dec 17, 2016·Hormones and Behavior·Hayley S Kamin, Darlene A Kertes
Jan 21, 2017·Fertility and Sterility·Iris LeeAnuja Dokras

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
N VitoratosP A Zourlas
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
G M PrelevićL Balint-Perić
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
F BernardiA R Genazzani
© 2022 Meta ULC. All rights reserved