SO(2) inhalation induces protein oxidation, DNA-protein crosslinks and apoptosis in rat hippocampus

Ecotoxicology and Environmental Safety
Nan SangGuangke Li

Abstract

Previous studies provide evidence for the possible neurotoxicity of SO(2), but little information is available about its mechanisms. In the present study, SO(2) inhalation-induced effects on the protein oxidation, DNA-protein crosslinks and apoptosis in rat hippocampus were studied, by exposing Wistar rats to SO(2) at 14, 28 and 56mg/m(3). The results indicate that the protein carbonyl content, an indicator of protein oxidation, and DNA-protein crosslink coefficient were significantly augmented with concentration-dependent properties. In addition, SO(2) inhalation at all concentrations tested caused the increases of caspase-3 activity and number of TUNEL positive staining neuron and the statistical difference was observed after 28 and 56mg/m(3) exposure, suggesting the occurrence of apoptosis. The results imply that attacking protein, nucleic acids and lipids by free radicals, generated via SO(2) derivatives in vivo, is one of the main mechanisms for SO(2)-induced injuries in central neuronal system.

References

Jan 14, 1972·Biochemical and Biophysical Research Communications·H Hayatsu, R C Miller
Dec 1, 1994·Environmental Health Perspectives·J L Farber
Nov 30, 1994·Biochemical and Biophysical Research Communications·X Shi, Y Mao
Jan 1, 1994·Immunology Today·T M Buttke, P A Sandstrom
Jan 1, 1997·Free Radical Biology & Medicine·R Meneghini
Jun 25, 1998·The Journal of Cell Biology·S TanD Schubert
Oct 6, 1999·Archives of Environmental Contamination and Toxicology·P YargiçoğluY Oğuz
Aug 12, 2000·Reviews on Environmental Health·D Schwela
Jul 14, 2001·Redox Report : Communications in Free Radical Research·R J Carmody, T G Cotter
Sep 15, 2001·Free Radical Biology & Medicine·N Andrieu-AbadieT Levade
Nov 14, 2001·Free Radical Biology & Medicine·G I GilesC Jacob
Dec 17, 2003·Archives of Environmental Contamination and Toxicology·Dongmei Wu, Ziqiang Meng
Feb 1, 2005·Biochimica Et Biophysica Acta·Michael J Davies
May 18, 2005·Environmental and Molecular Mutagenesis·Ziqiang MengBo Zhang
Jul 16, 2005·Inhalation Toxicology·Ichizo TsujinoAkinari Kaneko
Jan 1, 2003·Environmental Toxicology and Pharmacology·Ziqiang Meng, Bo Zhang

❮ Previous
Next ❯

Citations

Oct 22, 2013·Ecotoxicology and Environmental Safety·Wen-Jun ZhuShu Li
Jan 15, 2014·Chemico-biological Interactions·Ci LiuShu Li
Jan 15, 2014·Life Sciences·Xin-Bao WangHong Cui
Jul 1, 2015·European Journal of Pharmacology·Xin-Bao WangHong Cui
Mar 6, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chih-Yu TuTsu-Shing Wang
Jan 22, 2013·Chemosphere·Ming HanNan Sang
Oct 30, 2016·Toxicology Mechanisms and Methods·Ozlem OzsoyAysel Agar
Dec 30, 2016·Basic & Clinical Pharmacology & Toxicology·Arnold GroehlerNatalia Y Tretyakova
May 22, 2020·Chemical Communications : Chem Comm·Li Wang, Yang Chen
Apr 25, 2020·Environmental and Molecular Mutagenesis·Yusuke Kojima, Yuichi J Machida
Feb 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lu JiaQing-Zheng Yang
Aug 21, 2012·Toxicology and Industrial Health·Nihal UrenYunus Onal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis