Socheongryongtang suppresses COPD-related changes in the pulmonary system through both cytokines and chemokines in a LPS COPD model.

Pharmaceutical Biology
Soon-Young LeeDae-Hun Park

Abstract

Context: Socheongryongtang is a traditional Korean medical prescription used to treat pulmonary diseases.Objective: This study investigated the therapeutic mechanism of socheongryongtang for pulmonary diseases.Materials and methods: Seventy BALB/c mice were used: control, 0.8 mg/kg/study LPS intranasal instillation, 1 mg/kg/day Spiriva oral administration for five days, two socheongryongtang groups (150 or 1500 mg/kg/day orally treatment for five days). To illuminate the anti-COPD mechanism, several factors were evaluated such as WBC and differential counts in BALF and IgE in serum, morphological changes, and changes of COPD-related cytokines (TNF-α, IFN-γ, TGF-β) and chemokines (CXCL1, CCL-2, CCR2) in the lung. In order to confirm the statistical significance, all results were compared under p < 0.01 and p < 0.05.Results: LPS induced a high level of WBC, neutrophils and eosinophils in our in vivo study. Additionally, COPD related cytokines and chemokines such as TNF-α, IFN-γ, TGF-β, CXCL1, CCL-2 and CCR2 were induced by LPS. Compared to the LPS treatment group, socheongryongtang significantly controlled the level of WBC, neutrophils and eosinophils as well as the level of IgE. It effectively down-regulated the morphological ch...Continue Reading

References

Mar 1, 1997·Chest·C E McEvoy, D E Niewoehner
Mar 23, 2000·The Journal of Pathology·W I de BoerP S Hiemstra
Aug 1, 1956·Annals of Internal Medicine·W FRANKLINI W SCHILLER
Jun 25, 2004·The New England Journal of Medicine·James C HoggPeter D Paré
Aug 17, 2006·Trends in Pharmacological Sciences·Louise E Donnelly, Peter J Barnes
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease
Nov 21, 2007·COPD·Jørgen Vestbo
Feb 16, 2008·Nature Reviews. Immunology·Peter J Barnes
Oct 29, 2008·Annual Review of Pathology·James C Hogg, Wim Timens
Sep 1, 2009·American Journal of Respiratory Cell and Molecular Biology·Peter J Barnes
Dec 17, 2009·Lancet·Nicholas S Hopkinson, Michael I Polkey
Nov 16, 2010·Progress in Molecular Biology and Translational Science·Jian ZhangKenneth J Pienta
Aug 13, 2014·Expert Review of Respiratory Medicine·Kaosia NowrinEugene Haydn Walters
Sep 25, 2014·Respiratory Research·Victor KimGerard J Criner
May 5, 2017·Tobacco Induced Diseases·Vahideh GhoraniMajid Kianmeher
May 31, 2018·Experimental Lung Research·Javad BoskabadiMohammad Hossein Boskabady
Sep 28, 2018·Annals of Agricultural and Environmental Medicine : AAEM·Andrzej Bożek, Barbara Rogala
May 23, 2019·Respiratory Research·Saeideh SaadatMohammad Hossein Boskabady

❮ Previous
Next ❯

Citations

Mar 24, 2021·Scientific Reports·Marisa HakoupianXinhua Zhan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.