Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice

Genes, Brain, and Behavior
S S MoyJ N Crawley

Abstract

Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now-familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend- ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference fo...Continue Reading

References

Jul 1, 1989·Journal of Animal Science·J G Vandenbergh
Jan 1, 1986·American Journal of Medical Genetics·R J HagermanM Braden
Jun 1, 1985·Neurology·M Bauman, T L Kemper
Aug 3, 1973·Psychopharmacologia·L Valzelli
Apr 1, 1973·Journal of Autism and Childhood Schizophrenia·L Kanner
Aug 1, 1971·Psychological Reports·M L Cheal, R L Sprott
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·C S CarterL L Getz
Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Dec 1, 1993·Archives of Neurology·M HallettJ Rumsey
Aug 1, 1996·Physiology & Behavior·L L Liebenauer, B M Slotnick
Nov 14, 1998·Journal of Autism and Developmental Disorders·P SzatmariJ E MacLean
Jan 12, 1999·Neuroscience and Biobehavioral Reviews·G Laviola, M L Terranova
Jul 27, 1999·American Journal of Human Genetics·N RischR M Myers
Dec 3, 1999·American Journal of Medical Genetics·S BarrettS Slager
Jul 11, 2000·Nature Genetics·J N FergusonJ T Winslow
Oct 31, 2000·Journal of Autism and Developmental Disorders·J W BodfishM H Lewis
Jan 6, 2001·Neuron·C LordD G Amaral
Mar 10, 2001·Mental Retardation and Developmental Disabilities Research Reviews·H Tager-FlusbergS Folstein
Mar 17, 2001·Nature Reviews. Neuroscience·T R Insel, L J Young
Oct 27, 2001·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T R Insel
Dec 6, 2001·Nature Reviews. Genetics·S E Folstein, B Rosen-Sheidley
Jan 5, 2002·The Journal of Nutrition·Kristin A WaiteDennis E Vance
Feb 13, 2002·American Journal of Medical Genetics·Yujun ShaoMargaret A Pericak-Vance
Feb 22, 2002·American Journal of Medical Genetics·Anne PhilippeUNKNOWN Paris Autism Research International Sibpair Study
Mar 14, 2002·Developmental Psychobiology·James D ChurchillWilliam T Greenough
Jul 27, 2002·Molecular Psychiatry·L J YoungJ N Ferguson
Oct 3, 2002·Neuropeptides·J T Winslow, T R Insel
Nov 14, 2002·Behavioural Brain Research·J Adriaan Bouwknecht, Richard Paylor
Dec 5, 2002·Journal of Autism and Developmental Disorders·Grace T Baranek
Jan 7, 2003·Child and Adolescent Psychiatric Clinics of North America·Rhea Paul
Feb 26, 2003·European Journal of Pharmacology·Sandra E File, Pallab Seth
Feb 26, 2003·European Journal of Pharmacology·D Caroline BlanchardRobert J Blanchard

❮ Previous
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Citations

Sep 28, 2012·Journal of Autism and Developmental Disorders·Andrew M HeitzerMaria G Valdovinos
May 7, 2013·Neuropharmacology·Brian L TengSheryl S Moy
Nov 21, 2009·Molecular Brain·Oksana Kaidanovich-BeilinJames R Woodgett
Aug 29, 2006·PLoS Genetics·Steve D M BrownHilary Gates
Oct 8, 2011·PloS One·Jennifer T WolstenholmeEmilie F Rissman
Jul 26, 2012·PloS One·Jennifer BrielmaierJacqueline N Crawley
Mar 22, 2013·PloS One·Georgette L SuidanDenisa D Wagner
Mar 4, 2014·PloS One·Hisatsugu KoshimizuTsuyoshi Miyakawa
Dec 10, 2013·Behavioural Brain Research·David ChengTim Karl
Mar 7, 2014·Proceedings. Biological Sciences·Philipp BechsteinErik Maronde
Feb 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Alexander F JeansKay E Davies
Mar 14, 2013·EMBO Molecular Medicine·Anamaria SudarovMargaret Elizabeth Ross
Nov 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Weidong LiTyrone D Cannon
Apr 29, 2014·Journal of Psychiatric Research·Sebastian A GiustiDamian Refojo
Apr 5, 2012·EMBO Molecular Medicine·Nora HagemeyerHannelore Ehrenreich
Nov 26, 2014·Translational Psychiatry·J DachtlerS J Clapcote

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