Social aversive generalization learning sharpens the tuning of visuocortical neurons to facial identity cues.

ELife
Yannik StegmannMatthias J Wieser

Abstract

Defensive system activation promotes heightened perception of threat signals, and excessive attention to threat signals has been discussed as a contributory factor in the etiology of anxiety disorders. However, a mechanistic account of attentional modulation during fear-relevant processes, especially during fear generalization remains elusive. To test the hypothesis that social fear generalization prompts sharpened tuning in the visuocortical representation of social threat cues, 67 healthy participants underwent differential fear conditioning, followed by a generalization test in which participants viewed faces varying in similarity with the threat-associated face. We found that generalization of social threat sharpens visuocortical tuning of social threat cues, whereas ratings of fearfulness showed generalization, linearly decreasing with decreasing similarity to the threat-associated face. Moreover, individuals who reported greater anxiety in social situations also showed heightened sharpened tuning of visuocortical neurons to facial identity cues, indicating the behavioral relevance of visuocortical tuning during generalization learning.

References

Mar 1, 1994·Journal of Behavior Therapy and Experimental Psychiatry·M M Bradley, P J Lang
Aug 1, 1997·Behaviour Research and Therapy·R M Rapee, R G Heimberg
Apr 10, 1999·Nature Neuroscience·M M MüllerS A Hillyard
Aug 10, 2000·Psychophysiology·M JunghöferB Rockstroh
Nov 5, 2003·Psychological Methods·R Michael Furr, Robert Rosenthal
Dec 16, 2003·Cognitive, Affective & Behavioral Neuroscience·Andreas KeilPeter J Lang
Sep 29, 2004·Trends in Cognitive Sciences·Merav Ahissar, Shaul Hochstein
Sep 2, 2005·Nature Neuroscience·Gunter LofflerHugh R Wilson
Sep 6, 2005·Brain Research. Cognitive Brain Research·Stephan Moratti, Andreas Keil
Mar 10, 2006·Cerebral Cortex·Sharon Gilaie-Dotan, Rafael Malach
Sep 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·M M MüllerS A Hillyard
Jan 5, 2007·Psychological Bulletin·Yair Bar-HaimMarinus H van IJzendoorn
Jan 24, 2007·Psychophysiology·Almut I WeikeAlfons O Hamm
Jul 1, 2009·Psychiatry Research·Nim TottenhamCharles Nelson
Aug 12, 2009·Nature Neuroscience·Winrich A FreiwaldMargaret S Livingstone
Aug 15, 2009·Cognitive, Affective & Behavioral Neuroscience·Matthias J WieserAndreas Mühlberger
Nov 18, 2009·The American Journal of Psychiatry·Shmuel LissekChristian Grillon
Dec 25, 2009·Psychophysiology·Matthias J WieserAndreas Mühlberger
May 18, 2011·Computational Intelligence and Neuroscience·Peter PeykMarkus Junghöfer
Nov 8, 2012·Biological Psychology·David Torrents-RodasRafael Torrubia
Nov 28, 2012·Frontiers in Psychology·Margaret M BradleyPeter J Lang
Dec 4, 2012·Frontiers in Human Neuroscience·L Forest GrussAndreas Keil
Jun 5, 2013·Frontiers in Human Neuroscience·Oliver J RobinsonChristian Grillon
Jun 12, 2013·Social Cognitive and Affective Neuroscience·Shmuel LissekChristian Grillon
Jul 12, 2013·The Annals of Applied Statistics·Bradley Efron
Jul 31, 2013·The European Journal of Neuroscience·Andreas KeilJasna Martinovic
Sep 5, 2013·Biological Psychiatry·Shmuel LissekChristian Grillon
Oct 16, 2013·NeuroImage·Matthias J Wieser, Andreas Keil
Apr 26, 2014·Science·Daniel Baldauf, Robert Desimone
Jun 5, 2014·Frontiers in Bioscience (Elite Edition)·Bruno Rossion
Jun 5, 2015·Journal of Behavior Therapy and Experimental Psychiatry·Trisha BantinChristiane Hermann
Jun 14, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jürgen Kayser, Craig E Tenke
Jul 29, 2015·Nature Communications·Lisa M McTeagueAndreas Keil
Oct 16, 2015·Behavior Therapy·Daniella Tinoco-GonzálezRafael Torrubia

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Citations

Nov 23, 2020·NeuroImage·Matthias F J SperlErik M Mueller
Feb 26, 2021·Cognitive, Affective & Behavioral Neuroscience·Franziska Magdalena KauscheLars Schwabe
Jun 28, 2021·NeuroImage·Ashley A HugginsChristine L Larson
Aug 5, 2021·Scientific Reports·Yannik StegmannMatthias J Wieser

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Software Mentioned

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EMEGS ( Electro Magnetic Encephalography )

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