PMID: 26333258Sep 4, 2015Paper

Social Behaviour is Impaired in the R6/2 Mouse Model of Huntington’s Disease

Journal of Huntington's Disease
Nigel I Wood, A Jennifer Morton

Abstract

Huntington’s disease (HD) is characterised by a combination of motor, cognitive and psychiatric symptoms. HD patients also exhibit deficits in social behaviour. While motor and cognitive dysfunction in the R6/2 transgenic mouse model of HD has been well described, social disorders have not been reported. To compare social behaviour in R6/2 and wildtype (WT) mice, using two different measures of sociability. R6/2 mice were tested in the habituation/dishabituation test as a measure of social recognition, and the resident-intruder paradigm, as a measure of social interaction. In the social recognition test, WT mice remained interested in female mice throughout the testing period. Male R6/2 mice showed reduced interest in female mice from 14 weeks of age, while still recognising novel female mice. In the resident intruder test, R6/2 residents showed a lack of interest in the intruder. Interestingly, WT resident mice showed more aggressive behaviour towards R6/2 than WT intruders. This aggressive behaviour stopped once the barrier was removed, but WT mice showed increased risk assessment and escape behaviours while interacting with R6/2 intruders. R6/2 mice have deficits in social behaviours. Phenotypic male R6/2 mice show a decreas...Continue Reading

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