Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort.

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Lucy L RussellGenetic FTD Initiative, GENFI

Abstract

A key symptom of frontotemporal dementia (FTD) is difficulty interacting socially with others. Social cognition problems in FTD include impaired emotion processing and theory of mind difficulties, and whilst these have been studied extensively in sporadic FTD, few studies have investigated them in familial FTD. Facial Emotion Recognition (FER) and Faux Pas (FP) recognition tests were used to study social cognition within the Genetic Frontotemporal Dementia Initiative (GENFI), a large familial FTD cohort of C9orf72, GRN, and MAPT mutation carriers. 627 participants undertook at least one of the tasks, and were separated into mutation-negative healthy controls, presymptomatic mutation carriers (split into early and late groups) and symptomatic mutation carriers. Groups were compared using a linear regression model with bootstrapping, adjusting for age, sex, education, and for the FP recognition test, language. Neural correlates of social cognition deficits were explored using a voxel-based morphometry (VBM) study. All three of the symptomatic genetic groups were impaired on both tasks with no significant difference between them. However, prior to onset, only the late presymptomatic C9orf72 mutation carriers on the FER test were i...Continue Reading

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Citations

Aug 31, 2021·Brain Communications·Martina BocchettaJonathan D Rohrer
Nov 20, 2021·Journal of Neurology·Maria Antonietta MagnoMassimo Filippi
Nov 20, 2021·Journal of Neurology·Maria Antonietta MagnoFederica Agosta

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Software Mentioned

Statistical Parametric Mapping ( SPM )
SPM
Matlab
GENFI

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