Social Cognition Impairments in Patients with Multiple Sclerosis: Comparison with Grade of Disability

Neurology India
Ignatova G ValentinaTodorova P Lyudmila

Abstract

Social cognitive impairments are an essential aspect of general disability in patients with multiple sclerosis (MS). They can manifest independently or in addition to physical deficits. To examine the impairment of social cognition and its potential relationship with the grade of disability in MS patients. Our study included 17 healthy controls and 36 patients with clinically definite MS (relapsing-remittent form) according to the McDonald Criteria (2010). The patients were divided into two groups - patients with Expanded Disability Status Scale (EDSS) <3.5 (N = 18) and those with EDSS ≥3.5 (N = 18). The neuropsychological battery included empathy assessment (Self-Compassion, "Reading the Mind") and theory of mind tests - ToM (Faux pas, cartoons). We did not register a change in self-assessment empathy in MS. Reading the Mind in Eye test showed a clear tendency for deterioration with increasing physical disability. The statistically significant difference (P < 0.05) between the results of controls and patients with EDSS ≥3.5 was registered. The tests for interpreting stories perceived in an auditory manner ("faux pas") showed a clear trend toward "failure" among patients (P < 0.05). The results of patients with high disability ...Continue Reading

References

Nov 6, 1998·Journal of Cognitive Neuroscience·V E StoneR T Knight
Feb 17, 1999·The Journal of Neuropsychiatry and Clinical Neurosciences·C Diaz-OlavarrietaC Garcia de la Cadena
Nov 11, 2005·Acta Psychiatrica Scandinavica·N FigvedD Aarsland
Nov 15, 2008·Lancet Neurology·Nancy D Chiaravalloti, John DeLuca
Feb 11, 2009·Journal of the International Neuropsychological Society : JINS·Julie D HenryPeter G Rendell
Nov 20, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M BanatiZ Illes
Nov 26, 2010·Neuropsychology·Louise H PhillipsMoira Cook
Mar 29, 2011·Journal of Neurology·D ProchnowR J Seitz
Dec 3, 2011·Cognition·Idalmis SantiestebanGeoffrey Bird
Mar 3, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Eija Rosti-Otajärvi, Päivi Hämäläinen
Nov 7, 2012·Journal of Neuropsychology·Markus KraemerMona Abdel-Hamid
Jan 15, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Jana PöttgenStefan M Gold
Jan 1, 2013·Multiple Sclerosis and Related Disorders·A FeinsteinH Lassman
Jun 22, 2016·Neuropsychology Review·Emre BoraMark Walterfang

❮ Previous
Next ❯

Citations

Mar 5, 2020·Neurology India·Trey Walter Rose IiiMichael R Basso
Feb 3, 2021·The International Journal of Neuroscience·Triantafyllos DoskasΚonstantinos Vadikolias
Apr 27, 2021·Frontiers in Psychiatry·XiaoGuang LinZhongQuan Yi
May 8, 2021·Multiple Sclerosis and Related Disorders·XiaoGuang LinZhongQuan Yi
Oct 24, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Ornella ArgentoValerio Pisani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.