Social cognitive markers of short-term clinical outcome in first-episode psychosis

Clinical Schizophrenia & Related Psychoses
Tina MontreuilMartin Lepage

Abstract

In psychotic disorders, impairments in cognition have been associated with both clinical and functional outcome, while deficits in social cognition have been associated with functional outcome. As an extension to a recent report on neurocognition and short-term clinical outcome in first-episode psychosis (FEP), the current study explored whether social cognitive deficits could also identify poor short-term clinical outcome among FEP patients. We defined the social-cognition domain based on the scores from the Hinting Task and the Four Factor Tests of Social Intelligence. Data were collected in 45 FEP patients and 26 healthy controls. The patients were divided into good- and poor-outcome groups based on clinical data at six months following initiation of treatment. Social cognition was compared among 27 poor-outcome, 18 good-outcome, and 26 healthy-control participants. Outcome groups significantly differed in the social cognition domain (z-scores: poor outcome=-2.0 [SD=1.4]; good outcome=-1.0 [SD=1.0]; p=0.005), with both groups scoring significantly lower than the control group (p<0.003). Moreover, outcome groups differed significantly only on the Cartoon Predictions subtest (z-scores: poor outcome=-2.7 [SD=2.7]; good outcome=...Continue Reading

References

Nov 3, 1978·Science·D Premack, G Woodruff
May 1, 1993·Archives of General Psychiatry·J LiebermanM Borenstein
Mar 1, 1996·The American Journal of Psychiatry·M F Green
Jan 1, 1997·Psychological Bulletin·D L PennL Newman
Jun 6, 2000·Archives of General Psychiatry·J E SchwartzE J Bromet
May 25, 2002·Psychological Medicine·J S RubinszteinB J Sahakian
Jul 23, 2003·The Australian and New Zealand Journal of Psychiatry·Ashok MallaLaurel Townsend
Nov 9, 2004·Schizophrenia Research·James M Gold
Nov 9, 2004·Schizophrenia Research·Keith H NuechterleinRobert K Heaton
Sep 3, 2005·Schizophrenia Research·John BrekkeMichael F Green
Mar 7, 2006·Psychological Medicine·Ashok MallaRaj Haricharan
Aug 19, 2006·Schizophrenia Bulletin·Shannon M CoutureDavid L Roberts
Oct 3, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Jean AddingtonDonald Addington
Jul 17, 2007·Schizophrenia Research·Marie-Claude BertrandMartin Lepage
Jul 18, 2008·Social Neuroscience·Marie-Claude BertrandMartin Lepage
Aug 30, 2008·Schizophrenia Research·Heather K Horton, Steven M Silverstein
Oct 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Michael BodnarMartin Lepage

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Citations

Oct 2, 2015·Journal of Psychiatric Research·Ahmed El-MissiryHeba Essawy
Jan 30, 2013·Early Intervention in Psychiatry·Tina C MontreuilMartin Lepage
Oct 25, 2016·Clinical Psychology Review·Kristin M HealeyDavid L Penn
Apr 5, 2013·The Australian and New Zealand Journal of Psychiatry·Nikie Korver-NiebergLydia Krabbendam
Feb 26, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·M Giralt-LópezM Fatjó-Vilas
Jan 22, 2014·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Martin LepageChristopher R Bowie
Mar 9, 2021·Indian Journal of Psychiatry·Mahadev Singh SenSandeep Grover

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