Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

The European Journal of Neuroscience
S Montagud-RomeroMarta Rodríguez-Arias

Abstract

Social interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces long-lasting consequences that modify the reward system. First of all, we will describe the most characteristic results of the short- and long-term consequences of social defeat stress on the rewarding effects of drugs of abuse such as psychostimulants and alcohol. Secondly, and throughout the review, we will carefully assess the neurobiological mechanisms underlying these effects, including changes in the dopaminergic system, corticotrophin releasing factor signaling, epigenetic modifications and the neuroinflammatory response. To conclude, we will consider the ad...Continue Reading

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Citations

Jul 25, 2019·Frontiers in Behavioral Neuroscience·Carmen Ferrer-PérezMarta Rodríguez-Arias
Oct 19, 2020·Hormones and Behavior·M D ReguilónM Rodríguez-Arias
Mar 7, 2021·International Journal of Molecular Sciences·Carmen Ferrer-PérezMarta Rodríguez-Arias
May 12, 2021·The Journal of Headache and Pain·Yen-Feng WangShuu-Jiun Wang
Aug 15, 2021·Neuropharmacology·Pablo Giménez-GómezMarta Rodríguez-Arias

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