PMID: 9444483Jan 28, 1998Paper

Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences

Critical Reviews in Neurobiology
F S Hall

Abstract

This review examines the consequences of social deprivation on brain chemistry and behavior on rats. Although social deprivation produces wide-ranging behavioral and neurochemical effects, it appears that these effects are determined by a number of factors, the most critical factor being the age or developmental stage during the period of deprivation. Roughly, the effects examined in this review may be separated into three major developmental stages and each is related to deprivation of specific types of social interaction: preweaning/neonatal, postweaning/adolescent, and adult. The effects of social deprivation during each of these stages appears to be neurochemically and behaviorally specific. However, much of the research to date has failed to examine deprivation during specific stages, often combining deprivation of different types. Nonetheless, these modifications of experience produce animals of differing phenotypes, which could be characterized as pathological in nature in many instances, and may model particular aspects of human psychopathologies or perhaps the propensity to develop those phenotypic features.

Citations

Oct 3, 2009·Psychopharmacology·Bruno Ribeiro Do CoutoJose Miñarro
Oct 26, 2006·Behavior Genetics·Colin N HaileTherese A Kosten
Apr 16, 2004·Behavioural Brain Research·Therese A KostenPriscilla Kehoe
Jun 16, 2004·Behavioural Brain Research·Isabelle C WeissJoram Feldon
Jun 16, 2004·Behavioural Brain Research·Nicole C A SchrijverHanno Würbel
Jun 29, 2004·Behavioural Brain Research·Stéphanie BourgeonJacques-Olivier Coq
Jun 19, 2013·Neurochemistry International·Jelena Zlatković, Dragana Filipović
Jul 23, 2013·Neurobiology of Learning and Memory·Inmaculada Pereda-PérezCésar Venero
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·Andreas LengBoris Ferger
Sep 6, 2002·Physiology & Behavior·Bonnie J VastolaLinda P Spear
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·K PlojI Nylander
Jun 22, 2002·Pharmacology, Biochemistry, and Behavior·Nicole C A SchrijverHanno Würbel
Mar 20, 2003·Brain Research. Developmental Brain Research·Therese A KostenPriscilla Kehoe
Jan 27, 2004·Brain Research. Developmental Brain Research·Konrad LehmannGertraud Teuchert-Noodt
Mar 16, 2001·Trends in Neurosciences·H Würbel
Jul 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·O RilkeJ Oehler
Jul 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Molina-HernandezJ Perez-Garcia
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anne Michel, Ezio Tirelli

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