Social endophenotypes in autism spectrum disorder: A scoping review.

Development and Psychopathology
Gabrielle M Tiede, Katherine M Walton

Abstract

Endophenotypes are measurable markers of genetic vulnerability to current or future disorder. Autism spectrum disorder (ASD) is well-suited to be examined within an endophenotype framework given past and current emphases on the broader autism phenotype and early detection. We conducted a scoping review to identify potential socially-related endophenotypes of ASD. We focused on paradigms related to sociality (e.g., theory of mind (TOM), social attention), which comprise most of this literature. We integrated findings from traditional behavioral paradigms with brain-based measures (e.g., electroencephalography, functional magnetic resonance imaging). Broadly, infant research regarding social attention and responsivity (Research Domain Criteria (RDoC) domain of affiliation) and attention to faces and voices (social communication) finds consistent abnormality in vulnerable infant siblings. Several additional paradigms that have shown differences in vulnerable infants and young children include animacy perception tasks (perception and understanding of others), measures of recognition and response to familiar faces (attachment), and joint attention and false-belief tasks (understanding mental states). Research areas such as alexithym...Continue Reading

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Citations

Feb 13, 2021·Annual Review of Clinical Psychology·John N ConstantinoEmily J H Jones
Sep 16, 2021·Journal of Autism and Developmental Disorders·Irina PolyanskayaPatrick Blackburn

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