Social influences on morphine conditioned place preference in adolescent mice

Addiction Biology
Shannon L ColeShoshana Eitan

Abstract

Social/peer influences are among the strongest predictors of adolescent drug use. However, this important subject does not get much attention in pre-clinical studies. We recently observed that exposure to different social partners modulates morphine locomotor sensitization. Sensitivity to the hyper-locomotor response of drugs of abuse is a predictor of sensitivity to other drug-induced behaviors. Thus, this study examined how exposure to different social partners affected the rewarding properties of morphine. All animals were group-housed four per cage in one of two conditions referred to as 'only' and 'cage-mates'. In the mixed treatment condition, morphine- and saline-treated mice were housed together. These groups are referred to as 'morphine cage-mates' and 'saline cage-mates', respectively. In the separated treatment conditions, all mice in the cage received morphine (i.e. 'morphine only') or saline (i.e. 'saline only'), and cages were visually separated from each other. All animals were subsequently individually tested for the acquisition of morphine conditioned place preference (CPP) following one conditioning session with 10, 20 or 40 mg/kg morphine or saline. As expected, one conditioning session established morphine C...Continue Reading

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Apr 24, 2001·Pharmacology & Therapeutics·M NaritaT Suzuki
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Sep 30, 2014·Peptides·Richard J Bodnar
Oct 20, 2017·Behavioural Pharmacology·M L Shawn BatesShoshana Eitan
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Sep 2, 2020·Pharmacology, Biochemistry, and Behavior·Kyle A Windisch, Mary Jeanne Kreek
Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Shoshana EitanJacob Kuempel

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