PMID: 8474617Mar 1, 1993Paper

Social interaction and elevated plus-maze tests: changes in release and uptake of 5-HT and GABA

Neuropharmacology
S E FileN Andrews

Abstract

Changes in release and uptake of [3H]5-HT and [14C]GABA were compared in slices taken from the hippocampus and frontal cortex of rats, left undisturbed in their home-cages, or exposed for 5 min to the elevated plus-maze or social interaction tests of anxiety. Exposure to the plus-maze decreased cortical GABA function (shown by decreased release) and increased hippocampal 5-HT function (shown by increased K(+)-evoked release but more markedly by decreased uptake). Compared with undisturbed home cage controls, only the high light, familiar condition of the social interaction test resulted in a significant increase in K(+)-evoked release of both [3H]5-HT and [14C]GABA from the hippocampus. All four social interaction test conditions resulted in increases in cortical uptake of [3H]5-HT and all but the high light, unfamiliar condition increased cortical uptake of [14C]GABA. Analysing the two factors manipulated in the social interaction test, unfamiliarity with the test arena resulted in increased uptake of hippocampal [3H]5-HT and decreased cortical [14C]GABA, whereas an increase in the level of light decreased the cortical uptake of [14C]GABA. The results show that changes in presynaptic function occur rapidly in response to a bri...Continue Reading

Citations

Aug 1, 1993·Pharmacology, Biochemistry, and Behavior·S E FileN Andrews
Feb 1, 1995·Pharmacology, Biochemistry, and Behavior·C de Cabo de la VegaM Paz Viveros
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·S Hogg, S E File
May 1, 1994·Pharmacology, Biochemistry, and Behavior·S E File, N Andrews
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·R E GrahnS F Maier
Aug 1, 1996·Pharmacology, Biochemistry, and Behavior·P C YannielliD P Cardinali
Feb 26, 2003·European Journal of Pharmacology·Sandra E File, Pallab Seth
Nov 5, 1999·Physiology & Behavior·H De Souza SpinosaA Lucisano
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·S E FileS Cheeta
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·B J BowersJ M Wehner
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Josefina Sala-RocaFerran Balada
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·André RexHeidrun Fink
Nov 5, 1997·Pharmacology, Biochemistry, and Behavior·J GeR J Naylor
Mar 10, 1998·Neuroscience and Biobehavioral Reviews·A Ramos, P Mormède
Apr 1, 1997·Behavioural Brain Research·A RamosF Chaouloff
Jan 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·T J SajdykA Shekhar
Jan 27, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S KõksP T Männistö
Jul 15, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Iandra HolzmannMárcia Maria de Souza
Feb 24, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C A LazariniM M Bernardi
Sep 1, 2004·Neuroscience Letters·Margus TõnissaarJaanus Harro
Dec 15, 2004·Phytotherapy Research : PTR·Rosana M CosentinoCarlos A Lazarini
Oct 1, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Grazia MorgeseStefania Schiavone
Jun 5, 2004·European Journal of Pharmacology·David H OverstreetSandra Hogg
May 19, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M C B NorteC A Lazarini
Jul 13, 2000·Journal of Psychopharmacology·F Chaouloff

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