Social Interaction Improved by Oxytocin in the Subclass of Autism with Comorbid Intellectual Disabilities

Diseases
Haruhiro HigashidaM Kikuchi

Abstract

Approximately half of all autism spectrum disorder (ASD) individuals suffer from comorbid intellectual disabilities. Furthermore, the prevalence of epilepsy has been estimated to be 46% of patients with low intelligence quotient. It is important to investigate the therapeutic benefits and adverse effects of any recently developed drugs for this proportion of individuals with the so-called Kanner type of ASD. Therefore, we investigated the therapeutic and/or adverse effects of intranasal oxytocin (OT) administration, especially in adolescents and adults with ASD and comorbid intellectual disability and epilepsy, with regard to core symptoms of social deficits. We have already reported three randomized placebo-controlled trials (RCTs). However, we revisit results in our pilot studies from the view of comorbidity. Most of the intellectually disabled participants were found to be feasible participants of the RCT. We observed significantly more events regarded as reciprocal social interaction in the OT group compared with the placebo group. In the trial, no or little differences in adverse events were found between the OT and placebo arms, as found in some other reports. However, seizures were induced in three participants with medi...Continue Reading

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Citations

Dec 29, 2019·Cells·Haruhiro HigashidaOlga Lopatina
Feb 15, 2020·Communications Biology·Yasuhiko Yamamoto, Haruhiro Higashida
May 3, 2021·BMC Neuroscience·Stanislav M CherepanovHaruhiro Higashida
May 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Livia H MoraisJohn F Cryan

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