Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: Role of corticosterone, oxytocin, and vasopressin

Journal of Psychopharmacology
Brian H HarveyMarisa Möller

Abstract

The chronobiotic antidepressant, agomelatine, acts via re-entrainment of circadian rhythms. Earlier work has demonstrated late-life anxiety and reduced corticosterone in post-weaning social isolation reared (SIR) rats. Agomelatine was anxiolytic in this model but did not reverse hypocortisolemia. Reduced corticosterone or cortisol (in humans) is well-described in anxiety states, although the anxiolytic-like actions of agomelatine may involve targeting another mechanism. Central oxytocin and vasopressin exert anxiolytic and anxiogenic effects, respectively, and are subject to circadian fluctuation, while also showing sex-dependent differences in response to various challenges. If corticosterone is less involved in the anxiolytic-like actions of agomelatine in SIR rats, we wondered whether effects on vasopressin and oxytocin may mediate these actions, and whether sex-dependent effects are evident. Anxiety as assessed in the elevated plus maze, as well as plasma vasopressin, oxytocin, and corticosterone were analyzed in social vs SIR animals receiving sub-chronic treatment with vehicle or agomelatine (40 mg/kg/day intraperitoneally at 16:00) for 16 days. Social isolation rearing induced significant anxiety together with increased ...Continue Reading

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Citations

Jan 30, 2021·Life Sciences·Stephani C Wang, Yu-Feng Wang
Apr 15, 2020·Pharmacology, Biochemistry, and Behavior·Murilo S de AbreuAllan V Kalueff
Mar 19, 2021·Behavioural Brain Research·Fair M Vassoler, Elizabeth M Byrnes

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
pharmacotherapy

Software Mentioned

Graphpad Prism

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