Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Chuljung KwakBong-Kiun Kaang

Abstract

It is hypothesized that a number of environmental factors affect animals' behavior. Without controlling these variables, it is very hard for researchers to get not only reliable, but replicable data from various behavioral experiments testing animals' cognitive as well as emotional functions. For example, laboratory mice which had restricted environment showed different synaptic potentiation properties with wild mice (Zhao MG et al., 2009). While performing behavioral experiments, however, it is sometimes inevitable that the researcher changes the animals' environments, as by switching the cages in which experimental animals are housed and separating animals raised together into small experimental groups. In this study, we investigated the effect of environmental changes on mice's emotional behaviors by socially isolating them or reducing the size of their cage. We found that social isolation selectively increases the animals' levels of anxiety, while leaving depression-like behaviors unchanged. On the other hand, alteration of the housing dimensions affected neither their anxiety levels nor their depression-like behaviors. These results suggest that environmental variables may have a prominent impact on experimental animals' e...Continue Reading

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Citations

Apr 5, 2012·Genes, Brain, and Behavior·J L OnksenJ A Blendy
Jan 30, 2014·Journal of Pharmacological and Toxicological Methods·Luis HerediaJosé L Domingo
Jan 1, 2014·Journal of Pharmacological and Toxicological Methods·Luis HerediaJosé L Domingo
Apr 2, 2015·Behavioural Brain Research·Bruno PradierIldikó Rácz
Oct 26, 2012·Laboratory Animals·Paulin JirkofMargarete Arras
Jul 9, 2013·Experimental Neurobiology·Eun-Hae JangBong-Kiun Kaang
Jul 1, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sang Ho YoonMyoung-Hwan Kim
Mar 16, 2019·Annals of the New York Academy of Sciences·Gillian A Matthews, Kay M Tye
Feb 12, 2020·Scientific Reports·Paulin JirkofBrianna N Gaskill

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