Social isolation stress and neuroactive steroids.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Mariangela SerraGiovanni Biggio

Abstract

Social isolation of rats immediately after weaning is associated to a reduction in the cerebrocortical and plasma concentrations of progesterone and its metabolites 3alpha,5alpha-TH PROG and 3alpha,5alpha-THDOC. Although we found that the basal plasma concentration of adrenocorticotropic hormone in isolated rats was slightly decreased compared with that in group-housed animals no other significant changes were found in the steroidogenic machinery (peripheral benzodiazepine receptors, steroidogenic regulatory protein (StAR)). However, the functional response of the hypothalamic-pituitary-adrenal axis HPA axis to an acute stressful stimulus (foot shock), or to an acute injection of ethanol or isoniazid is markedly increased in isolated rats. Behavioral studies have also indicated that the ability of ethanol to inhibit isoniazid-induced convulsions is greater in isolated rats than in group-housed animals and this effect of isolation is prevented by treatment with the 5alpha-reductase inhibitor finasteride. Social isolation modified the effects of ethanol on the amounts of StAR mRNA and protein in the brain suggesting an alteration in the mechanism of cholesterol transport in mitochondria. Moreover, the amounts of the alpha4 and de...Continue Reading

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Citations

May 9, 2012·Acta Neuropathologica·Venugopal Reddy VennaLouise D McCullough
Jun 19, 2013·Neurochemistry International·Jelena Zlatković, Dragana Filipović
Jul 23, 2013·Neurobiology of Learning and Memory·Inmaculada Pereda-PérezCésar Venero
Sep 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·D ChandraG E Homanics
Jul 10, 2010·International Journal of Environmental Research and Public Health·Allison M J Anacker, Andrey E Ryabinin
Jul 16, 2013·Journal of Neural Transmission·Jelena ZlatkovićDragana Filipović
Apr 29, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jelena ZlatkovićDragana Filipović
Jun 6, 2012·Hormones and Behavior·Louise C HawkleyJohn T Cacioppo
Aug 12, 2008·Medical Hypotheses·Hajime Fukui, Kumiko Toyoshima
Feb 19, 2008·Psychoneuroendocrinology·Andras Bilkei-GorzoAndreas Zimmer
Nov 6, 2007·Neurochemistry International·Roberto Cosimo Melcangi, Ayikoe Guy Mensah-Nyagan
Sep 18, 2015·Current Psychiatry Reports·Liisa Hantsoo, C Neill Epperson
Aug 17, 2014·Neuropharmacology·Paul D WhissellBeverley A Orser
Apr 14, 2009·Hormones and Behavior·Stephanie L BrownOliver C Schultheiss
Nov 9, 2016·Maturitas·Dr Jenifer Sassarini
Nov 13, 2017·Pharmacological Reports : PR·Anna Gądek-MichalskaJan Bugajski
May 28, 2020·The Journal of Experimental Biology·Alexis C ExumJens Herberholz
Mar 29, 2014·Molecular and Cellular Biochemistry·Jelena ZlatkovićDragana Filipović

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