Social isolation, vital exhaustion, and incident heart failure: findings from the Atherosclerosis Risk in Communities Study.

European Journal of Heart Failure
Crystal W CenéGiselle Corbie-Smith

Abstract

Prospective studies have shown that social isolation (i.e. lack of social contacts) predicts incident coronary heart disease (CHD), but it is unclear whether it predicts incident heart failure (HF) and what factors might mediate this association. HF patients may be more susceptible to social isolation as they tend to be older and may have disrupted social relationships due to life course factors (e.g. retirement or bereavement). We prospectively examined whether individuals with higher vs. low social isolation have a higher incidence of HF and determined whether this association is mediated by vital exhaustion. We estimated incident HF hospitalization or death among 14 348 participants from Visit 2 (1990-1992) in the Atherosclerosis Risk in Communities (ARIC) study using Cox proportional hazard models which were sequentially adjusted for age, race/study community, gender, current smoking, alcohol use, and co-morbidities. We conducted mediation analyses according to the Baron and Kenny method. After a median follow-up of 16.9 person-years, 1727 (13.0%) incident HF events occurred. The adjusted hazard of incident HF was greater for those in the higher vs. low social isolation risk group (hazard ratio 1.21, 95% confidence interval...Continue Reading

References

Apr 1, 1992·Journal of Epidemiology and Community Health·S L Wong, S P Donnan
Jan 1, 1991·Journal of Psychosomatic Research·R van Diest, A Appels
Jul 29, 1988·Science·J S HouseD Umberson
Oct 1, 1987·International Journal of Cardiology·A AppelsP Mulder
May 1, 1995·Psychosomatic Medicine·L F Berkman
Dec 1, 1993·Journal of Psychosomatic Research·A AppelsE G Schouten
Jan 1, 1993·Psychosomatic Medicine·K Orth-GomérL Wilhelmsen
Mar 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·K RäikkönenA Hautanen
Jan 13, 1997·Archives of Internal Medicine·H M KrumholzJ Hennen
Mar 1, 1997·Journal of the American Geriatrics Society·R B BurnsM Finch
Jan 30, 1999·Psychoneuroendocrinology·S S Knox, K Uvnäs-Moberg
Dec 22, 1999·The American Journal of Cardiology·S R ColeI M Lee
Feb 13, 2001·European Heart Journal·K F FoxG C Sutton
Jun 19, 2004·Scandinavian Cardiovascular Journal : SCJ·Roland von KänelJoachim Fischer
Jan 28, 2009·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 11, 2009·Stroke; a Journal of Cerebral Circulation·Martin Dichgans, Robert A Hegele
Jun 12, 2010·The American Journal of Cardiology·Janice E WilliamsWayne D Rosamond

❮ Previous
Next ❯

Citations

Dec 30, 2015·Health & Social Care in the Community·Emilie Courtin, Martin Knapp
Jun 29, 2016·Journal of the American Geriatrics Society·S Goya WannametheePeter H Whincup
Dec 3, 2016·Psychosomatic Medicine·Daria Frestad, Eva Prescott
Aug 21, 2014·Stroke; a Journal of Cerebral Circulation·Mako NagayoshiPamela L Lutsey
Dec 25, 2015·Circulation. Heart Failure·Rachel P OgilviePamela L Lutsey
Aug 29, 2017·Psychosomatic Medicine·Renzo BianchiEric Laurent
Apr 23, 2020·Journal of the American Heart Association·Madeline R SterlingParag Goyal
Jul 20, 2018·Frontiers in Psychology·Jessica SchochUlrike Ehlert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.