Social motility in african trypanosomes.

PLoS Pathogens
Michael OberholzerKent L Hill

Abstract

African trypanosomes are devastating human and animal pathogens that cause significant human mortality and limit economic development in sub-Saharan Africa. Studies of trypanosome biology generally consider these protozoan parasites as individual cells in suspension cultures or in animal models of infection. Here we report that the procyclic form of the African trypanosome Trypanosoma brucei engages in social behavior when cultivated on semisolid agarose surfaces. This behavior is characterized by trypanosomes assembling into multicellular communities that engage in polarized migrations across the agarose surface and cooperate to divert their movements in response to external signals. These cooperative movements are flagellum-mediated, since they do not occur in trypanin knockdown parasites that lack normal flagellum motility. We term this behavior social motility based on features shared with social motility and other types of surface-induced social behavior in bacteria. Social motility represents a novel and unexpected aspect of trypanosome biology and offers new paradigms for considering host-parasite interactions.

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·V B Carruthers, G A Cross
Jan 1, 1988·Biology of the Cell·K VickermanC M Turner
Apr 1, 1985·British Medical Bulletin·K Vickerman
Aug 1, 1994·Molecular Microbiology·R M Harshey
Nov 1, 1996·Journal of Bacteriology·O RauprichJ A Shapiro
Mar 13, 1998·Molecular and Biochemical Parasitology·B ReunerM Boshart
Jan 19, 1999·Annual Review of Microbiology·J A Shapiro
Dec 23, 1999·Current Opinion in Microbiology·G M Fraser, C Hughes
Feb 1, 2000·Parasitology Today·M Parsons, L Ruben
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·M H Rashid, A Kornberg
Jul 13, 2000·Current Opinion in Genetics & Development·R A Firtel, R Meili
Feb 7, 2001·Science·T B Reynolds, G R Fink
Feb 28, 2002·The Journal of Cell Biology·Nathan R HutchingsKent L Hill
Jul 20, 2002·The Lancet Infectious Diseases·Dominique LegrosPhilippe Büscher
Apr 10, 2003·Eukaryotic Cell·Kent L Hill
Sep 5, 2003·Nature·Gregory J Velicer, Yuen-Tsu N Yu
Oct 7, 2003·Annual Review of Microbiology·Rasika M Harshey
Mar 26, 2004·Nature Reviews. Microbiology·Dale Kaiser
Sep 11, 2004·Current Molecular Medicine·T SeebeckA Johner
Jul 5, 2005·Science·Eric NudlemanDale Kaiser
Jul 16, 2005·Science·Matthew BerrimanNajib M El-Sayed
Oct 21, 2005·Journal of Bacteriology·Nicky C CaiazzaG A O'Toole
Apr 25, 2006·Cell·Bonnie L Bassler, Richard Losick
Jul 22, 2006·Biochemical Society Transactions·W GibsonM Bailey
Oct 24, 2006·Current Opinion in Microbiology·Jill R Blankenship, Aaron P Mitchell
Dec 19, 2006·Trends in Parasitology·Michael OberholzerThomas Seebeck
Aug 24, 2007·Current Biology : CB·Gad Shaulsky, Richard H Kessin
Oct 9, 2007·Nature Reviews. Microbiology·David R ZusmanJohn R Kirby
Feb 27, 2008·Parasites & Vectors·Wendy GibsonMick Bailey
Jul 16, 2008·Current Opinion in Microbiology·Isabel Roditi, Michael J Lehane
Sep 9, 2008·Trends in Microbiology·Natalie VerstraetenJan Michiels
Oct 17, 2008·Nature Reviews. Microbiology·Michael L GingerPaul G McKean
Jan 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Avraham Be'erHarry L Swinney
Jul 7, 2009·Annual Review of Microbiology·Katherine S RalstonKent L Hill

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Citations

Jun 17, 2014·Nature Reviews. Microbiology·Gerasimos Langousis, Kent L Hill
Dec 30, 2015·Protist·Adriana BoteroR C Andrew Thompson
Oct 25, 2011·Current Opinion in Microbiology·Miguel A LopezKent L Hill
Oct 5, 2015·Trends in Parasitology·Simon Imhof, Isabel Roditi
Nov 3, 2015·Seminars in Cell & Developmental Biology·Timothy Krüger, Markus Engstler
Jul 7, 2011·Biology of the Cell·Cathy Fisch, Pascale Dupuis-Williams
Oct 19, 2013·Cellular Microbiology·Brice RotureauPhilippe Bastin
Jul 2, 2010·Current Opinion in Microbiology·Kent L Hill
May 26, 2015·Trends in Parasitology·Laura Makin, Eva Gluenz
Feb 14, 2016·The Journal of Eukaryotic Microbiology·Guillermo Paz-Y-Miño-C, Avelina Espinosa
Mar 20, 2013·Trends in Parasitology·Naomi A DyerAlvaro Acosta-Serrano
Apr 9, 2017·Molecular and Biochemical Parasitology·G Srinivas ReddyChinmoy Sankar Dey
Mar 4, 2017·PLoS Pathogens·Dror EliazShulamit Michaeli
May 1, 2016·Current Opinion in Microbiology·Isabel RoditiArunasalam Naguleswaran
Apr 30, 2015·MBio·Michael OberholzerKent L Hill
Aug 3, 2019·Journal of Cell Science·Benjamin J Walker, Richard J Wheeler
Dec 19, 2015·PLoS Pathogens·Edwin A SaadaKent L Hill
May 1, 2019·Parasites & Vectors·Mathieu CaylaKeith R Matthews
Mar 20, 2018·Physical Review. E·Adyant Agrawal, Sujin B Babu
Aug 3, 2018·MSphere·Xiuhong FengScott M Landfear
Mar 20, 2019·Journal of Cell Science·Adela S Oliva ChávezJoao H F Pedra
Jun 21, 2019·Current Medicinal Chemistry·Alejandra Cecilia SchoijetGuillermo Daniel Alonso
Apr 3, 2020·Microbiology and Molecular Biology Reviews : MMBR·Felice D KellyScott M Landfear
Feb 1, 2017·PLoS Computational Biology·Richard John Wheeler
Jun 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Stella Y SunCynthia Y He
Apr 19, 2018·Essays in Biochemistry·Michael J Cipriano, Stephen L Hajduk
Feb 20, 2019·Nature Communications·Sebastian ShawKent L Hill
Mar 24, 2021·The European Physical Journal. E, Soft Matter·Timothy KrügerMarkus Engstler

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