PMID: 6538980Feb 1, 1984Paper

Social play in juvenile rats during scopolamine withdrawal

Physiology & Behavior
D H Thor, W R Holloway

Abstract

Scopolamine induced blockade of play fighting in juvenile rats and the rapid induction of behavioral tolerance to an initially effective dosage suggested a rebound in social play following chronic scopolamine exposure. Juvenile rats received daily intraperitoneal scopolamine or saline injections for one week. Play soliciting and play fighting behavior were then measured at 24 and 168 hr after drug withdrawal. Scopolamine treated juveniles engaged in markedly greater play soliciting and play fighting behavior than did controls. Drug-induced increase in muscarinic receptors and supersensitivity to endogenous acetylcholine following scopolamine withdrawal is suggested as the basis for observed differences in social play.

References

Sep 1, 1979·Psychopharmacology·Z S Herman, J Słominska-Zurek
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Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·W W BeattyJ Panksepp
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Nov 1, 1982·Pharmacology, Biochemistry, and Behavior·W W Beatty, K B Costello
Apr 1, 1983·Physiology & Behavior·D H Thor, W R Holloway
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·C C LoullisR T Bartus
Aug 1, 1982·Physiology & Behavior·D H Thor, W R Holloway
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Citations

May 1, 1986·Pharmacology, Biochemistry, and Behavior·L I WilsonW W Beatty
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·D H Thor, W R Holloway
Jan 1, 1987·Neurotoxicology and Teratology·W R Holloway, D H Thor
Mar 1, 1988·Neurotoxicology and Teratology·W R Holloway, D H Thor
May 1, 1997·Neuroscience and Biobehavioral Reviews·L J VanderschurenJ M Van Ree
Nov 6, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Priti N Patel, Danielle C Ezzo
Oct 24, 1998·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·T KoyamaT Hiekata

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