Social reward-conditioned place preference: a model revealing an interaction between cocaine and social context rewards in rats.

Drug and Alcohol Dependence
Kenneth J ThielJanet L Neisewander

Abstract

A recent thrust in drug abuse research is the influence of social interactions on drug effects. Therefore, the present study examined conditioned place preference (CPP) as a model for assessing interactions between drug and social rewards in adolescent rats. Parameters for establishing social reward-CPP were examined, including the number of conditioning sessions/day (1 or 2), the total number of sessions (2, 8, or 16), and the duration of sessions (10 or 30 min). Subsequently, the effects of cocaine or dextromethorphan on social reward-CPP and play behavior were examined. The results demonstrate that social reward-CPP (i.e., preference shift for an environment paired previously with a rat) was similar using either 1 or 2 conditioning sessions/day and either 10 or 30 min sessions; however, social reward-CPP increased as the number of social pairings increased. Additionally, a low dose of cocaine (2 mg/kg, IP) and a low number of social pairings (2 pairings) failed to produce CPP when examined alone, but together produced a robust CPP, demonstrating an interaction between these rewards. The non-rewarding drug, dextromethorphan (30 mg/kg, IP), failed to enhance social reward-CPP, suggesting that drug-enhanced social reward-CPP is...Continue Reading

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Citations

Feb 19, 2009·Psychopharmacology·Kenneth J ThielJanet L Neisewander
Aug 15, 2009·Psychopharmacology·Gillinder BediHarriet de Wit
Jul 20, 2011·Experimental and Clinical Psychopharmacology·Cassandra D GipsonMichael T Bardo
Aug 7, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Viviana TrezzaLouk J M J Vanderschuren
Feb 16, 2013·Behavioural Pharmacology·Geoffrey W PeitzMark A Smith
Jun 30, 2012·PloS One·E J Marijke AchterbergLouk J M J Vanderschuren
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Viviana TrezzaLouk J M J Vanderschuren
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Viviana TrezzaLouk J M J Vanderschuren
Feb 21, 2014·Psychopharmacology·Viviana TrezzaLouk J M J Vanderschuren
Dec 7, 2013·Psychopharmacology·Petra J J BaarendseLouk J M J Vanderschuren
Jan 28, 2014·Psychopharmacology·Jessica J Stanis, Susan L Andersen
May 29, 2013·Psychopharmacology·Matthew G Kirkpatrick, Harriet de Wit
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Mar 23, 2012·Developmental Cognitive Neuroscience·Viviana TrezzaLouk J M J Vanderschuren
May 2, 2015·Behavioural Pharmacology·Mark A SmithRyan T Lacy
Jul 26, 2011·Pharmacology, Biochemistry, and Behavior·N S PentkowskiJ L Neisewander

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