Social separation and diazepam withdrawal increase anxiety in the elevated plus-maze and serotonin turnover in the median raphe and hippocampus

Journal of Psychopharmacology
Lucinéia dos SantosFrederico G Graeff

Abstract

The present work aimed to evaluate the effects of social separation for 14 days (chronic stress) and of withdrawal from a 14-day treatment with diazepam (acute stress) on the exploratory behaviour of male rats in the elevated plus-maze and on serotonin (5-hydroxytryptamine) turnover in different brain structures. Social separation had an anxiogenic effect, evidenced by fewer entries into, and less time spent on the open arms of the elevated plus-maze. Separation also selectively increased 5-hydroxytryptamine turnover in the hippocampus and median raphe nucleus. Diazepam withdrawal had a similar anxiogenic effect in grouped animals and increased 5-hydroxytryptamine turnover in the same brain structures. Chronic treatment with imipramine during the 14 days of separation prevented the behavioural and neurochemical changes caused by social separation. It is suggested that the increase in anxiety determined by both acute and chronic stress is mediated by the activation of the median raphe nucleus-hippocampal 5-hydroxytryptamine pathway.

References

Oct 1, 1978·Physiology & Behavior·F G Graeff, N G Silveira Filho
Jul 1, 1994·Trends in Pharmacological Sciences·P Blier, C de Montigny
Jul 1, 1993·Trends in Pharmacological Sciences·F Artigas
Jan 12, 1999·Neuroscience and Biobehavioral Reviews·F G GraeffH Zangrossi
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P Blier, C de Montigny
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·R C TeixeiraF G Graeff
Nov 7, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·P NettesheimT Gray
Sep 22, 2001·Pharmacology, Biochemistry, and Behavior·T G Andrade, F G Graeff
Aug 31, 2002·Psychopharmacology·Franco BorsiniDonatella Marazziti
Jun 29, 2004·Behavioural Brain Research·Telma G C S AndradeFrederico G Graeff
Jun 1, 2005·Behavioural Brain Research·Denovan P BeggTrevor R Norman
Jun 14, 2005·Behavioural Brain Research·T G C S AndradeF G Graeff
Jun 1, 2007·Pharmacology, Biochemistry, and Behavior·Luiz F S Souza-PintoManoel Jorge Nobre
Aug 3, 2007·Brain Research·Lucas Baptista FontanesiManoel Jorge Nobre
Aug 31, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lucinéia Dos SantosHélio Zangrossi Junior
Jan 23, 2008·Journal of Psychopharmacology·S N PinheiroF G Graeff
Apr 9, 2008·Behavioural Brain Research·Sven Ove OgrenOliver Stiedl
Jun 24, 2008·Behavioural Brain Research·Jason Hannon, Daniel Hoyer

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Citations

Aug 7, 2013·Journal of Pain and Symptom Management·Simone A HendriksJenny T van der Steen
Nov 15, 2012·Brain Research Bulletin·Jovana DivljakovićMiroslav M Savić
Jun 30, 2015·Behavioural Brain Research·Soaleha ShamsRobert Gerlai
Dec 31, 2011·Neuroscience and Biobehavioral Reviews·Dominik KiserJudith R Homberg
Nov 1, 2011·Neuroscience and Biobehavioral Reviews·Thibault RenoirLaurence Lanfumey
May 21, 2013·Physiology & Behavior·Winanda W UrsinusCornelis G van Reenen
Feb 11, 2015·Physiology & Behavior·Soliani Flaviane Cristina de Brito GuzzoAndrade Telma Gonçalves Carneiro Spera de
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Farhan MohammadAdam Claridge-Chang
Sep 4, 2013·Journal of Psychopharmacology·Telma Gcs AndradeFrederico G Graeff
Jun 15, 2019·The Journal of Comparative Neurology·Debora BuenoMartin Metzger
May 12, 2021·Integrative and Comparative Biology·Sarah E D DavisLaura M Hurley

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