Social stress alters the severity and onset of the chronic phase of Theiler's virus infection

Journal of Neuroimmunology
R R JohnsonM W Meagher

Abstract

Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.

References

Jan 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·I GrantM R Trimble
Sep 1, 1985·Journal of Behavioral Medicine·R GlaserJ E Holliday
Sep 1, 1987·Psychosomatic Medicine·J K Kiecolt-GlaserC E Speicher
Nov 1, 1993·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·R GlaserJ K Kiecolt-Glaser
May 5, 2001·Epidemiology·M A HernánA Ascherio
May 26, 2001·Hormones and Behavior·R AvitsurJ F Sheridan
Apr 18, 2002·Journal of Neuroimmunology·Jennifer L StarkJohn F Sheridan
Jul 18, 2002·Infection·J GutiérrezM C Maroto
Nov 1, 2002·Journal of the Neurological Sciences·Henrik GonzalezTomas Olsson
Nov 6, 2002·Journal of Neuroimmunology·Ronit AvitsurJohn F Sheridan
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Lynn I LevinAlberto Ascherio
Jan 22, 2005·Neurologic Clinics·Amit Bar-Or

❮ Previous
Next ❯

Citations

Oct 10, 2013·Current Neurology and Neuroscience Reports·Jesus Lovera, Tara Reza
May 2, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Crystal M NollerPhilip M McCabe
Jun 29, 2007·Trauma, Violence & Abuse·Mary W MeagherC Jane Welsh
Nov 30, 2018·Psychological Medicine·Sun Jae JungKarestan C Koenen
Mar 20, 2020·Acta Neurologica Scandinavica·Saúl ReyesGavin Giovannoni
Jan 24, 2019·International Journal of Molecular Sciences·Ingo GerhauserAndreas Beineke
Jul 28, 2020·Reviews in the Neurosciences·Berenice Anabel SilvaCarina Cintia Ferrari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.