Social stress increases the acquisition of cocaine self-administration in male and female rats

Brain Research
M HaneyP V Piazza

Abstract

The effect of social stress on the vulnerability to commence cocaine self-administration was examined in Sprague-Dawley rats repeatedly exposed to aggressive attack by a same-sex opponent. Both sexes were studied, since the factors influencing the acquisition of drug self-administration in females have not been defined. Male and female rats encountered an aggressive male or lactating female opponent on four separate occasions over the course of one week. Control male and female rats were not exposed to attack. All animals were implanted with jugular catheters, and six days later placed into the self-administration box, where a nose-poke in the designated 'active hole' resulted in a 20 microliters injection of cocaine (0.32 mg/kg). Nose-pokes in an 'inactive' hole had no effect. Male and female rats that had experienced social stress self-administered more cocaine than non-defeated controls. The difference between the stressed and non-stressed animals in the number of cocaine injections was not present during the first few days of exposure to cocaine, but became more pronounced over time. Social stress increased the number of responses for cocaine, but did not alter the number of non-specific responses. Sex differences in self-a...Continue Reading

References

Jan 1, 1979·Physiology & Behavior·B F Schneider, S Norton
Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·Y ShahamN E Grunberg
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P V PiazzaH Simon
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·J M DeminiereH Simon
Jan 8, 1966·Nature·A W Burke, P L Broadhurst
Jan 1, 1981·Pharmacology, Biochemistry, and Behavior·M M Savageau, W W Beatty

❮ Previous
Next ❯

Citations

Feb 14, 2007·Psychopharmacology·Jasmine J Yap, Klaus A Miczek
Oct 3, 2009·Psychopharmacology·Bruno Ribeiro Do CoutoJose Miñarro
Aug 13, 2010·Sleep & Breathing = Schlaf & Atmung·Mohammad M AminAvram R Gold
Apr 16, 2004·Behavioural Brain Research·Therese A KostenPriscilla Kehoe
Jun 4, 2013·Behavioural Brain Research·Christel WestenbroekJill B Becker
Nov 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nick E Goeders
Oct 18, 2000·European Journal of Pharmacology·R StamV M Wiegant
Jul 5, 2001·Physiology & Behavior·R J BlanchardD C Blanchard
Jul 20, 2002·Physiology & Behavior·Monika TrzcińskaRichard H Melloni
Aug 31, 2001·Pharmacology, Biochemistry, and Behavior·W J LynchM E Carroll
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Kelly P CosgroveMarilyn E Carroll
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·S Schenk, B Partridge
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Ph De WitteP Verbanck
Mar 12, 1998·Brain Research. Brain Research Reviews·P V Piazza, M Le Moal
Mar 20, 2003·Brain Research. Developmental Brain Research·Therese A KostenPriscilla Kehoe
Apr 29, 1998·Trends in Pharmacological Sciences·P V Piazza, M Le Moal
Dec 26, 2001·Psychoneuroendocrinology·Nick E Goeders
Aug 10, 2000·Drug and Alcohol Dependence·N E GoedersG F Guerin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.