PMID: 9539804May 16, 1998Paper

Social stress results in altered glucocorticoid regulation and shorter survival in simian acquired immune deficiency syndrome

Proceedings of the National Academy of Sciences of the United States of America
John P CapitanioWilliam A Mason

Abstract

From early in the AIDS epidemic, psychosocial stressors have been proposed as contributors to the variation in disease course. To test this hypothesis, rhesus macaques were assigned to stable or unstable social conditions and were inoculated with the simian immunodeficiency virus. Animals in the unstable condition displayed more agonism and less affiliation, shorter survival, and lower basal concentrations of plasma cortisol compared with stable animals. Early after inoculation, but before the emergence of group differences in cortisol levels, animals receiving social threats had higher concentrations of simian immunodeficiency virus RNA in plasma, and those engaging in affiliation had lower concentrations. The results indicate that social factors can have a significant impact on the course of immunodeficiency disease. Socially induced changes in pituitary-adrenal hormones may be one mechanism mediating this relationship.

References

Nov 24, 1990·BMJ : British Medical Journal·G W RutherfordL S Doll
Apr 1, 1990·AIDS Research and Human Retroviruses·P A FurthL Hennighausen
Jan 1, 1988·Annual Review of Microbiology·R C Desrosiers
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·P D MarkhamR C Gallo
Nov 1, 1984·The American Psychologist·T J CoatesJ Mandel
Apr 15, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C PachlB Irvine
Jul 1, 1995·The American Journal of Psychiatry·R YehudaE L Giller
Jun 18, 1994·Lancet·M ClericiG Norbiato
May 1, 1993·Psychosomatic Medicine·C L Coe
Apr 1, 1993·American Journal of Public Health·G M Herek, J P Capitanio
Nov 1, 1995·Psychosomatic Medicine·M E KemenyJ L Fahey

❮ Previous
Next ❯

Citations

Jul 30, 2002·Primates; Journal of Primatology·John P Capitanio
May 21, 2013·Cellular and Molecular Life Sciences : CMLS·Jenny Tung, Yoav Gilad
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jonathan P Godbout, Ronald Glaser
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joan W BermanWalter Royal
Mar 31, 2004·Brain, Behavior, and Immunity·Kathy L KopniskyDianne M Rausch
Apr 20, 2000·Applied Animal Behaviour Science·S J SchapiroK J Sastry
Feb 23, 2012·Journal of Comparative Psychology·Tamara A R Weinstein, John P Capitanio
Mar 2, 2005·Nature Reviews. Immunology·Ronald Glaser, Janice K Kiecolt-Glaser
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Steven W ColeJohn T Cacioppo
Feb 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert M DonahoeHarold H McClure
Sep 15, 2007·Genome Biology·Steve W ColeJohn T Cacioppo
Nov 13, 2003·Journal of Applied Animal Welfare Science : JAAWS·Steven J SchapiroGail E Laule
Apr 2, 2010·Demography·Dora L Costa, Matthew E Kahn
Aug 8, 2013·PloS One·Sarah PattersonFrederick M Hecht
Aug 10, 2013·American Journal of Public Health·Steven W Cole
Mar 9, 2012·Molecular Medicine·Blake T GurfeinDouglas F Nixon
Dec 17, 2003·Biological Psychiatry·Steve W ColeBruce D Naliboff
Apr 3, 2001·Journal of Neuroimmunology·N QuanJ F Sheridan
Dec 20, 2011·Hormones and Behavior·Adam S Smith, Zuoxin Wang
Dec 11, 2007·Brain, Behavior, and Immunity·Erica K SloanSteve W Cole
Aug 19, 2007·Brain, Behavior, and Immunity·Erica K SloanSteve W Cole
Sep 27, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Torunn BrulandAre Dalen
Apr 10, 2009·Autism Research : Official Journal of the International Society for Autism Research·Blythe A CorbettSally Mendoza
Aug 26, 2011·Developmental Psychobiology·Ton G G Groothuis, Fritz Trillmich
Apr 28, 2012·American Journal of Primatology·John P Capitanio
Aug 19, 2010·American Journal of Primatology·John P Capitanio
Sep 10, 2011·American Journal of Primatology·Steven J Schapiro, Bruce J Bernacky
Aug 14, 2012·Developmental Psychobiology·Jessica J VandeleestJohn P Capitanio
Aug 3, 2005·Neuroscience and Biobehavioral Reviews·P E Honess, C M Marin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.