PMID: 2508158Jan 1, 1989Paper

Social withdrawal following amphetamine administration to marmosets

Psychopharmacology
L E AnnettH F Baker

Abstract

Approaches and leaves from social encounters by marmosets which had received amphetamine injected either intramuscularly or into the nucleus accumbens or caudate nucleus were recorded and used to determine whether social behaviour was disrupted as a result of behavioural competition or more active social withdrawal. The social isolation observed after the marmosets had received an IM injection of amphetamine (2 mg/kg) was not due to drug-induced increases in alternative behaviours. Drugged animals immediately withdrew from social encounters, interrupting their stereotypies in order to do so, whenever they were approached by an undrugged animal. In contrast, the reduced time spent in social encounters following amphetamine injections into the nucleus accumbens (10, 20 or 40 micrograms) appeared to be a direct consequence of the concurrent increase in locomotion. Animals continued to initiate social encounters despite being hyperactive. Amphetamine injections into the caudate nucleus were without effect on any of the social or individual behavioural measures.

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Citations

Mar 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·C H StuppaeckW Poewe
May 1, 1992·Pharmacology, Biochemistry, and Behavior·G J CareyR J Naylor
Aug 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·T ShinbaT Hoshino
Feb 22, 2002·Behavioural Pharmacology·M Li, D E McMillan
Oct 2, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stacy A Castner, Graham V Williams

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