Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship

Journal of Neurophysiology
Sarah M Keesom, Laura M Hurley

Abstract

Cues from social partners trigger the activation of socially responsive neuromodulatory systems, priming brain regions including sensory systems to process these cues appropriately. The fidelity with which neuromodulators reflect the qualities of ongoing social interactions in sensory regions is unclear. We addressed this issue by using voltammetry to monitor serotonergic fluctuations in an auditory midbrain nucleus, the inferior colliculus (IC), of male mice (Mus musculus) paired with females, and by concurrently measuring behaviors of both social partners. Serotonergic activity strongly increased in male mice as they courted females, relative to serotonergic activity in the same males during trials with no social partners. Across individual males, average changes in serotonergic activity were negatively correlated with behaviors exhibited by female partners, including broadband squeaks, which relate to rejection of males. In contrast, serotonergic activity did not correlate with male behaviors, including ultrasonic vocalizations. These findings suggest that during courtship, the level of serotonergic activity in the IC of males reflects the valence of the social interaction from the perspective of the male (i.e., whether the ...Continue Reading

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Citations

Nov 14, 2016·Hearing Research·Richard A FelixChristine V Portfors
May 9, 2018·Journal of Neuroendocrinology·Carlos A Rodríguez-SaltosDonna L Maney
Sep 1, 2017·Journal of Neurophysiology·Sarah M KeesomLaura M Hurley
May 14, 2020·Journal of Neurophysiology·Tyler R SizemoreAndrew M Dacks
Oct 7, 2017·Integrative and Comparative Biology·Christopher L Petersen, Laura M Hurley
Oct 10, 2020·Frontiers in Behavioral Neuroscience·Alexandra C NiemczuraJeffrey J Wenstrup
May 12, 2021·Integrative and Comparative Biology·Sarah E D DavisLaura M Hurley

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