Socially modulated cell proliferation is independent of gonadal steroid hormones in the brain of the adult green treefrog (Hyla cinerea)

Brain, Behavior and Evolution
Lynn M Almli, Walter Wilczynski

Abstract

Gonadal steroid hormones have been shown to influence adult neurogenesis in addition to their well-defined role in regulating social behavior. Adult neurogenesis consists of several processes including cell proliferation, which can be studied via 5-bromo-2'-deoxyuridine (BrdU) labeling. In a previous study we found that social stimulation altered both cell proliferation and levels of circulating gonadal steroids, leaving the issue of cause/effect unclear. In this study, we sought to determine whether socially modulated BrdU-labeling depends on gonadal hormone changes. We investigated this using a gonadectomy-implant paradigm and by exposing male and female green treefrogs (Hyla cinerea) to their conspecific chorus or control stimuli (i.e. random tones). Our results indicate that socially modulated cell proliferation occurred independently of gonadal hormone levels; furthermore, neither androgens in males nor estrogen in females increased cell proliferation in the preoptic area (POA) and infundibular hypothalamus, brain regions involved in endocrine regulation and acoustic communication. In fact, elevated estrogen levels decreased cell proliferation in those brain regions in the implanted female. In male frogs, evoked calling be...Continue Reading

References

May 1, 1976·General and Comparative Endocrinology·M WadaA Gorbman
Oct 1, 1992·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·J D Allison
Jan 1, 1989·Brain, Behavior and Evolution·W Wilczynski, J D Allison
Sep 1, 1986·General and Comparative Endocrinology·L IelaJ T Bagnara
Aug 1, 1973·General and Comparative Endocrinology·Y S Palka, A Gorbman
Jan 1, 1966·Behaviour·R S Schmidt
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S A Goldman, F Nottebohm
Jan 20, 1983·The Journal of Comparative Neurology·T J Neary, R G Northcutt
Jan 1, 1984·General and Comparative Endocrinology·R PierantoniR K Rastogi
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·S RasikaA Alvarez-Buylla
Feb 24, 1998·Biology of Reproduction·A M Polzonetti-MagniS Kikuyama
May 27, 1999·Brain, Behavior and Evolution·S B Emerson, S K Boyd
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·X C LiF Nottebohm
Feb 13, 2001·General and Comparative Endocrinology·J Chu, W Wilczynski
Nov 3, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S J SalekJ Godwin
Nov 22, 2001·Hormones and Behavior·S S Burmeister, W Wilczynski
Nov 28, 2001·The European Journal of Neuroscience·M BanasrA Daszuta
Apr 5, 2002·Journal of Neurobiology·Christie D FowlerZuoxin Wang
Jun 6, 2002·Behavioural Brain Research·D LipkindA Barnea
Nov 11, 2003·Journal of Neurobiology·Christie D FowlerZuoxin Wang
Mar 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Benjamín Alvarez-BordaFernando Nottebohm
Oct 19, 2004·Brain, Behavior and Evolution·Sabrina S Burmeister, Walter Wilczynski

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Citations

Feb 16, 2016·Frontiers in Neuroendocrinology·Melissa M Holmes
Jun 16, 2014·Social Science & Medicine·Ray PawsonElizabeth Glidewell
Sep 26, 2017·Frontiers in Neuroscience·Mariela Faykoo-MartinezMelissa M Holmes

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