Society of Dermatology Hospitalists supportive care guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults.

Journal of the American Academy of Dermatology
Lucia Seminario-VidalRobert G Micheletti

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions with high morbidity and mortality. Supportive care management of SJS/TEN is highly variable. A systematic review of the literature was performed by dermatologists, ophthalmologists, intensivists, and gynecologists with expertise in SJS/TEN to generate statements for supportive care guideline development. Members of the Society of Dermatology Hospitalists with expertise in SJS/TEN were invited to participate in a modified, online Delphi-consensus. Participants were administered 9-point Likert scale questionnaires regarding 135 statements. The RAND/UCLA Appropriateness Method was used to evaluate and select proposed statements for guideline inclusion; statements with median ratings of 6.5 to 9 and a disagreement index of ≤1 were included in the guideline. For the final round, the guidelines were appraised by all of the participants. Included are an evidence-based discussion and recommendations for hospital setting and care team, wound care, ocular care, oral care, urogenital care, pain management, infection surveillance, fluid and electrolyte management, nutrition and stress ulcer prophylaxis, airway management, and anticoagulation...Continue Reading

Citations

Oct 22, 2020·JAMA Dermatology·Robert G Micheletti, Megan H Noe
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Shanshan WeiWenqun Li
Jul 27, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·Z RidhaE Netchiporouk
Sep 9, 2021·International Journal of Dermatology·Ken Cheah Hooi LeeDuu Wen Sewa
Sep 7, 2021·Journal of the American Academy of Dermatology·Jane J HanArash Mostaghimi

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