Socio-demographic, Clinical, and Genetic Determinants of Quality of Life in Lung Cancer Patients

Scientific Reports
Jeanne A PierzynskiMichelle A T Hildebrandt

Abstract

Patient reported health-related quality of life (QOL) is a major component of the overall well-being of cancer patients, with links to prognosis. In 6,420 lung cancer patients, we identified patient characteristics and genetic determinants of QOL. Patient responses from the SF-12 questionnaire was used to calculate normalized Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. Further, we analyzed 218 single nucleotide polymorphisms (SNPs) in the p38 MAPK signaling pathway, a key mediator of response to cellular and environmental stress, as genetic determinants of QOL in a subset of the study population (N = 641). Trends among demographic factors for mean PCS and MCS included smoking status (PCS Ptrend < 0.001, MCS Ptrend < 0.001) and education (PCS Ptrend < 0.001, MCS Ptrend < 0.001). Similar relationships were seen for MCS. The homozygous rare genotype of MEF2B: rs2040562 showed an increased risk of a poor MCS (OR: 3.06, 95% CI: 1.05-8.92, P = 0.041). Finally, survival analysis showed that a low PCS or a MCS was associated with increased risks of five-year mortality (HR = 1.63, 95% CI: 1.51-1.77, HR = 1.23, 95% CI: 1.16-1.32, respectively) and there was a significant reduction in median survival time (...Continue Reading

References

Apr 16, 1998·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M R Visser, E M Smets
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P Hopwood, R J Stephens
Mar 4, 2000·Journal of Pain and Symptom Management·M E Cooley
May 2, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H LangendijkM Wouters
Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A S CoatesA Goldhirsch
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A MontazeriC R Gillis
Sep 22, 2001·Brain, Behavior, and Immunity·E P ZorrillaK Schmidt
May 8, 2003·Heart & Lung : the Journal of Critical Care·Lorraine S EvangelistaJenny Chen
Sep 15, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BrownM D Peake
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Jan 18, 2006·Archives of Otolaryngology--head & Neck Surgery·Hisham M Mehanna, Randall P Morton
Feb 3, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chong-Bin ZhuWilliam A Hewlett
Mar 22, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W JacotUNKNOWN OncoLR health network
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hushan YangXifeng Wu
Sep 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James E HerndonElectra D Paskett
Oct 11, 2008·Nature Reviews. Cancer·Bostjan SerugaIan F Tannock
Dec 26, 2008·Methods in Molecular Biology·Ping Yang
Aug 12, 2009·Trends in Molecular Medicine·Lydia R CoulthardSusan A Burchill
Sep 18, 2009·Journal of Cancer Survivorship : Research and Practice·Nancy K JanzSteven J Katz
Oct 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin MovsasDeborah Watkins Bruner
Mar 9, 2010·Urology·Chanita H HalbertAndrea Troxel
Mar 30, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Camilla ZimmermannIan Tannock
Jul 6, 2010·American Journal of Human Genetics·Jimmy Z LiuStuart Macgregor
Jan 17, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jun ChenPing Yang
Feb 3, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Massimo Di MaioCesare Gridelli
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeff A SloanPing Yang
Apr 3, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sarah M RauschPing Yang
Oct 24, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Cecilia PompiliAlessandro Brunelli
Jun 19, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kinsey LamAndrew Bottomley
Jun 25, 2013·Genes, Brain, and Behavior·A J RashidS A Josselyn
Jul 23, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Suzana Sales De AguiarInês Echenique Mattos
Dec 3, 2016·Nucleic Acids Research·UNKNOWN The Gene Ontology Consortium

❮ Previous
Next ❯

Citations

May 10, 2020·Scientific Reports·Nerea Fernández de Larrea-BazMarina Pollán
Dec 29, 2020·Frontiers in Psychology·Chiara MarzoratiGabriella Pravettoni

❮ Previous
Next ❯

Methods Mentioned

BETA
environmental stress
genotyping

Software Mentioned

VEGAS
STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Ozioma C OkonkwoGeorge Howard
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Jorge D MachicadoGeorgios I Papachristou
© 2022 Meta ULC. All rights reserved