Abstract
Deferoxamine (DFO) is an iron chelator used to treat iron overload in patients receiving chronic blood transfusions, and is usually administered as overnight subcutaneous infusions. ISOSFER was a prospective, observational, cross-sectional study conducted in metropolitan France that evaluated patient characteristics, quality of life (QoL), compliance and patient satisfaction with DFO monotherapy. Of 70 patients with either thalassemia, sickle cell disease or myelodysplastic syndromes, 30% were 'satisfied' or 'very satisfied' with DFO. Patients' SF-36 scores were lower than those of the general French population, and lower among patients with comorbidities and those dissatisfied with treatment. Although 72% of patients had good compliance to DFO, 57% reported missing at least one infusion in the previous month, and 82% of patients expressed a preference for oral therapy. These results suggest that QoL is severely compromised in patients receiving DFO, and that compliance is not optimal.
References
Jan 1, 1986·Medical Care·D E MoriskyD M Levine
Dec 1, 1994·Baillière's Clinical Haematology·V Gabutti, C Borgna-Pignatti
Jan 1, 1996·Acta Haematologica·V Gabutti, A Piga
Nov 17, 1998·Journal of Clinical Epidemiology·A LeplègeT V Perneger
Dec 2, 2000·Transfusion Science·W BreuerZ I Cabantchik
Apr 25, 2001·European Journal of Clinical Pharmacology·R ArborettiUNKNOWN Italian Colaborative Group on Thalassarmia
Nov 13, 2001·British Journal of Haematology·J B Porter
Apr 30, 2002·Acta Haematologica·J Jaime CaroAndroulla Eleftheriou
May 23, 2002·BMC Clinical Pharmacology·Alexandra WardAndroulla Eleftheriou
Sep 30, 2006·Health and Quality of Life Outcomes·Linda AbetzDiana Rofail
Aug 19, 2007·Clinical Therapeutics·Maria Domenica CappelliniJean-Francois Baladi
Sep 21, 2007·Transfusion·Thomas E DeleaThomas D Coates
Apr 15, 2008·Acta Haematologica·Elliott VichinskyJean-Francois Baladi
May 30, 2008·Current Medical Research and Opinion·Luciana ScaloneMaria D Cappellini
Citations
Dec 5, 2013·The Clinical Journal of Pain·Marsha J TreadwellSan Keller
Oct 26, 2011·European Journal of Haematology·Norbert GattermannUlrich Germing
Apr 5, 2016·Transfusion·Diana WeidlichJulian F Guest
May 1, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·B FilhonJ-P Vannier
May 30, 2012·Clinical Journal of Oncology Nursing·Mary Laudon ThomasKaren Campbell
Nov 19, 2014·Pediatrics·Kathleen E WalshDavid G Bundy