Sociodemographic and clinical characteristics associated with vitamin D status in newly diagnosed pediatric cancer patients.

Pediatric Hematology and Oncology
Paula AristizabalMaria Elena Martinez

Abstract

Vitamin D deficiency and insufficiency are associated with serious sequelae in childhood cancer survivors. However, data on vitamin D deficiency in children with newly diagnosed cancer are scarce and the role of sociodemographic factors and vitamin D supplementation is largely unknown. We assessed vitamin D status and its socio-demographic and clinical correlates in 163 children with newly diagnosed cancer, using 25-hydroxy vitamin D (25(OH)D) concentrations and assessed longitudinal changes following vitamin D supplementation. Sixty-five percent of the patients with newly diagnosed cancer had low 25(OH)D concentrations. Fifty-two patients (32%) were vitamin D deficient (≤20 ng/mL 25(OH)D concentration), and 53(33%) were insufficient (21-29 ng/mL 25(OH)D concentration). Age over 10 (P = 0.019), Hispanic ethnicity (P = 0.002), and female sex (P = 0.008) were significantly associated with lower 25(OH)D concentration at diagnosis. Vitamin D supplementation resulted in significant increase in 25(OH)D concentrations (P < 0.001). However, following supplementation in the longitudinal analysis, this increase was less pronounced in Hispanic patients vs. non-Hispanic (P = 0.007), and in children with solid tumors vs. hematological malig...Continue Reading

References

Jun 24, 2006·The Oncologist·Brigitte C Widemann, Peter C Adamson
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Jan 8, 2008·Journal of Pediatric Hematology/oncology·Paulina R DíazDunny M Casanova
Mar 11, 2008·The American Journal of Clinical Nutrition·Elizabeth T JacobsMaría Elena Martínez
Apr 11, 2008·The American Journal of Clinical Nutrition·Joseph E Zerwekh
Jul 11, 2008·The American Journal of Clinical Nutrition·Marian L NeuhouserRachel Ballard-Barbash
Feb 13, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jacqueline HaltonUNKNOWN Canadian STOPP Consortium
Mar 25, 2009·Archives of Internal Medicine·Adit A GindeCarlos A Camargo
Sep 18, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O M GutiérrezE N Taylor
Feb 5, 2011·Pediatric Blood & Cancer·Akash SinhaTim Cheetham
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Dec 23, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N C WrightJ R Curtis
May 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Smita BhatiaF Lennie Wong
Nov 30, 2012·Pediatric Blood & Cancer·Abha ChoudharyCharles Sklar
Dec 1, 2012·European Journal of Endocrinology·O MäkitieK Jahnukainen
May 21, 2013·Annals of the New York Academy of Sciences·Sylvia ChristakosDaniel D Bikle
Jul 5, 2013·Journal of Pediatric Hematology/oncology·Marieka HelouGita Massey
Nov 7, 2013·Pediatric Blood & Cancer·Adam J EsbenshadeDebra L Friedman
Feb 2, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·R Revuelta IniestaD C Wilson
Mar 27, 2015·Pediatric Blood & Cancer·Fang Fang ZhangSusan B Roberts
Jul 15, 2015·The Journal of Clinical Endocrinology and Metabolism·Elizabeth A CummingsUNKNOWN Canadian STOPP Consortium (National Pediatric Bone Health Working Group)
Jun 1, 2014·Journal of Clinical and Translational Hepatology·Alla Grigorian, Christopher B O'Brien
Dec 16, 2016·The British Journal of Nutrition·Raquel Revuelta IniestaDavid C Wilson
Sep 30, 2017·Pediatric Blood & Cancer·Kristen BeebeAlexander Ngwube
May 8, 2018·Journal of Pediatric Hematology/oncology·Jennifer YoungRalph Salloum

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Citations

Jun 3, 2021·Nutrients·Alexandra PodpeskarChristina Salvador

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