Socioeconomic effects on the risk of having a recognized pregnancy with Down syndrome

Birth Defects Research. Part A, Clinical and Molecular Teratology
C Torfs, R E Christianson


Appoximately 95% of Down syndrome (DS) cases are caused by an error in germ cell division (meiosis), resulting in an extra chromosome 21. The meiotic error, predominantly of maternal origin, occurs either during the mother's fetal life (meiosis I) or at ovulation (meiosis II). Because maternal-age-specific DS prevalence rates vary between and within populations, it has been hypothesized that environmental factors can affect the risk for a DS pregnancy. In a population-based case-control study of 997 clinically recognized DS cases (including fetal losses) and 1007 controls without a birth defect, we examined the mother's socioeconomic status (SES) from the time of her fetal life to the time of conception. SES variables were considered as proxies for environmental factors. We used multiple logistic regression for the analyses. We found associations with low levels of each SES variable examined: mother's education less than high school (OR, 1.29; 95% CI, 1.01-1.65), father's low occupation (OR, 1.23; 95% CI, 0.95-1.60), father's low education (OR, 1.28; 95% CI, 0.99-1.64), mother's father's low occupation (OR, 1.35; 95% CI, 1.06-1.71), and family income <$20,000 (OR, 1.31; 95% CI, 1.02-1.68) [corrected]. The risk for DS increased ...Continue Reading


Dec 1, 1991·American Journal of Obstetrics and Gynecology·J L SimpsonA Bitto
Apr 1, 1988·American Journal of Medical Genetics·P A Baird, A D Sadovnick
Sep 27, 1986·British Medical Journal·R B EversonC Weinberg
Jan 1, 1987·Journal of Chronic Diseases·J L StanfordR Brookmeyer
Mar 1, 1985·American Journal of Epidemiology·Z A Stein
Sep 1, 1985·Annals of Internal Medicine·S M McKinlayJ B McKinlay
Apr 1, 1967·The Journal of Pediatrics·A T SiglerW H Hetznecker
Mar 1, 1974·American Journal of Epidemiology·S Harlap
Apr 1, 1981·Developmental Medicine and Child Neurology·L E Sever, I Emanuel
Aug 1, 1994·Maturitas·D J TorgersonD M Reid
Jul 1, 1993·Environmental Health Perspectives·A Vermeulen
Jan 1, 1994·American Journal of Epidemiology·R LuotoA Uutela
Jan 15, 1997·American Journal of Epidemiology·J BishopJ Deddens
Mar 8, 1997·BMJ : British Medical Journal·M S SchimmelC Hammerman
Oct 27, 1999·Epidemiology·G S CooperM Bohlig
Mar 29, 2000·Clinical Genetics·T Hassold, S Sherman
Jun 30, 2000·American Journal of Human Genetics·J KlineD Warburton
Oct 31, 2000·Epidemiology·J D Cragan, M J Khoury
Dec 29, 2000·American Journal of Epidemiology·C P Torfs, R E Christianson
May 5, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Q YangS B Freeman

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