Socioeconomic status, gender and dementia: The influence of work environment exposures and their interactions with APOE ɛ4

SSM - Population Health
Caroline HasselgrenBjörn Halleröd

Abstract

It is a well-established fact that unfavourable social and economic conditions have a negative impact on health and longevity. Recent findings suggest that this is also true of age-related dementias. Yet most common indicators of socioeconomic status (SES) say very little about the actual mechanisms at play in disease development. The present paper explores five work exposure characteristics, all of which have a clear social gradient, that could potentially shed further light on the relationship between SES and dementia. Specifically, it investigates whether these exposures could moderate the impact of a well-known genetic risk factor: the APOE ɛ4 allele. The empirical analyses are based on data from a Swedish population study (n = 1019). Main occupation was linked to The Job Exposure Matrix to estimate the individuals' exposure to the following work environment factors: work control, support, psychological demands, physical demands and job hazards. All analyses were conducted using binary logistic regression and focused specifically on gene-work exposure interactions. A significant main effect of work control on dementia risk was detected for males (OR = 0.68; p< 0.05), but not for females. However, control was found to signif...Continue Reading

Citations

Jun 12, 2019·Aging & Mental Health·Kirsten Nabe-NielsenRudi G J Westendorp
Dec 29, 2019·Alzheimer's Research & Therapy·A C van LoenhoudW M van der Flier
Sep 16, 2020·European Journal of Public Health·Katherine J FordAnja K Leist
Oct 11, 2020·Scandinavian Journal of Medicine & Science in Sports·Kirsten Nabe-NielsenÅse Marie Hansen
Feb 6, 2021·Neurobiology of Aging·Maria Victoria Marca-YsabelMargaret A Pericak-Vance
Jun 22, 2021·Journal of Alzheimer's Disease : JAD·Tzayaka Castillo-MendietaChristian Guerra-Araiza
Aug 15, 2021·Journal of Aging and Health·Andreas M AppelKirsten Nabe-Nielsen

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Methods Mentioned

BETA
PCR
genotyping

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