SOCS proteins and caveolin-1 as negative regulators of endocrine signaling

Trends in Endocrinology and Metabolism : TEM
Jean-François JasminMichael P Lisanti

Abstract

Recently, a new class of regulatory molecules has emerged; these molecules, termed SOCS proteins, function as suppressors of cytokine signaling. SOCS proteins negatively regulate the Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling cascade. Interestingly, it appears that other proteins, such as caveolin-1, can also function as suppressors of cytokine signaling by inhibiting the kinase activity of JAK family members. This might result from the ability of caveolin-1 to function as a broad-spectrum kinase inhibitor through the caveolin-scaffolding domain.

References

Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P E SchererM P Lisanti
Jun 26, 1997·Nature·R StarrD J Hilton
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·D J HiltonN A Nicola
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NarazakiT Kishimoto
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·R StarrW S Alexander
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·T NakaT Kishimoto
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J G ZhangM Baca
Oct 20, 1999·Cellular and Molecular Life Sciences : CMLS·D J Hilton
Mar 14, 2000·Current Opinion in Cell Biology·A S Edwards, J D Scott
Apr 27, 2000·Molecular Immunology·K Imada, W J Leonard
May 24, 2000·The Journal of Biological Chemistry·B EmanuelliE Van Obberghen
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S E NicholsonM Baca
Jul 13, 2000·Nature·D MetcalfW S Alexander
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·E Felley-BoscoA F Quest
Feb 15, 2001·The Prostate·J CuiA R Brothman
Feb 22, 2001·The Journal of Experimental Medicine·A SuzukiA Yoshimura
Jul 18, 2001·The Journal of Biological Chemistry·B RazaniM P Lisanti
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·A W RobertsW S Alexander
Aug 11, 2001·Biochemical Society Transactions·B RazaniM P Lisanti
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A E KarlsenN Billestrup
Jun 25, 2002·Oncogene·Robert RottapelPaulo de Sepulveda
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·You-Yang ZhaoKenneth R Chien
May 20, 2003·Nature Immunology·Hideo YasukawaAkihiko Yoshimura

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Citations

Apr 9, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jing HuangRajamma Mathew
Jun 11, 2011·Pulmonary Medicine·Rajamma Mathew
Mar 3, 2012·Digestive Diseases and Sciences·M SasikalaD Nageshwar Reddy
Sep 9, 2015·Biomedical Journal·Christophe Lamaze, Stéphanie Torrino
Feb 5, 2010·Experimental Lung Research·Jing HuangRajamma Mathew
Apr 17, 2007·Trends in Endocrinology and Metabolism : TEM·Gema FrühbeckCarlos Diéguez
May 17, 2008·Cancer Letters·Elke BurgermeisterMatthias P A Ebert
Jan 24, 2009·The American Journal of Pathology·Federica SotgiaMichael P Lisanti
Mar 22, 2014·Biochemical Society Transactions·Jamie J L Williams, Timothy M Palmer
Nov 10, 2009·Biochemical and Biophysical Research Communications·Hayeong Kwon, Yunbae Pak
Apr 18, 2007·Cardiology in Review·Rajamma MathewMichael H Gewitz
Feb 18, 2010·Cardiology in Review·Rajamma Mathew
Apr 14, 2010·Bioorganicheskaia khimiia·I A KostanianV M Lipkin
Jul 24, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sanda A PredescuAsrar B Malik
May 23, 2019·Cell Cycle·Sunaho OkadaHemal H Patel
Oct 29, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Rajamma Mathew
Aug 15, 2012·Experimental Biology and Medicine·Jing HuangRajamma Mathew

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