SOCS1 in cancer: An oncogene and a tumor suppressor

Cytokine
Claudia BeaurivageCaroline Saucier

Abstract

The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene.

References

Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·R StarrW S Alexander
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·T NakaT Kishimoto
Apr 5, 2000·The Journal of Biological Chemistry·P De SepulvedaR Rottapel
Sep 13, 2001·Stem Cells·D L Krebs, D J Hilton
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·X Peter ChenPaul Rothman
Sep 14, 2002·The Journal of Biological Chemistry·Liangyou RuiMorris F White
Apr 3, 2003·Immunological Reviews·Subburaj Ilangumaran, Robert Rottapel
May 22, 2003·Genes, Chromosomes & Cancer·Chien-Yuan ChenHwei-Fang Tien
Apr 13, 2004·Journal of Gastroenterology·Shinichi FujitakeAkimasa Nakao
May 4, 2004·Japanese Journal of Clinical Oncology·Toshiaki KomazakiTadamitsu Kishimoto
Aug 12, 2004·Molecular Cell·André LimnanderPaul B Rothman
Sep 18, 2004·The Journal of Investigative Dermatology·Zhuo LiMarkus Böhm
Nov 16, 2004·Seminars in Immunology·Subburaj IlangumaranRobert Rottapel
Sep 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio RussoUNKNOWN TP53-CRC Collaborative Study Group
Oct 27, 2006·The Journal of Molecular Diagnostics : JMD·Shuji OginoCharles S Fuchs
May 26, 2007·Nature Reviews. Immunology·Akihiko YoshimuraMasato Kubo
Jun 27, 2007·The Journal of Molecular Diagnostics : JMD·Shuji OginoCharles S Fuchs
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Lidija Klampfer
Aug 30, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrea BaetzAlexander H Dalpke
May 15, 2009·Nature Reviews. Cancer·Tarek Abbas, Anindya Dutta
Jun 12, 2009·Molecular Immunology·Christian KoelscheAlexander H Dalpke
Dec 17, 2009·Molecular Cell·Viviane CalabreseGerardo Ferbeyre
Apr 28, 2010·Gastroenterology·Janos TerzićMichael Karin
Jun 12, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jimmy BernierCaroline Saucier
Sep 24, 2010·Gastroenterology Research and Practice·Minoru Fujimoto, Tetsuji Naka
Apr 2, 2011·Cell Death and Differentiation·A FurlanF Maina
Apr 5, 2011·Translational Oncology·Jorge A Borin ScuttiLuiz R Travassos
May 24, 2011·Cancer Immunology, Immunotherapy : CII·Kristan D GuenterbergWilliam E Carson
Jun 28, 2011·Journal of Hepatology·Yirui GuiSubburaj Ilangumaran

❮ Previous
Next ❯

Citations

Mar 22, 2016·Cytokine·Subburaj Ilangumaran, Gerardo Ferbeyre
May 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sheng-Jia Yu, Zi-Wen Long
Apr 10, 2018·Journal of Molecular Recognition : JMR·Ramakrishna DumpatiUma Vuruputuri
Jan 24, 2019·Biomarkers in Medicine·Ziba Nariman-Saleh-FamJavad Tavakkoli-Bazzaz
May 28, 2019·Life Science Alliance·Bonnie L BullockRaphael A Nemenoff
Jan 19, 2018·International Journal of Oncology·Kosuke TaketoKazuhiko Ogawa
Jan 5, 2020·Nature Communications·Antonio ColapricoElena Papaleo
Dec 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Xinnan WuQing Ji
May 19, 2019·Cancer Research·Emmanuelle Saint-GermainGerardo Ferbeyre
Apr 20, 2021·Heliyon·Ahmed A EmamAhmed M A El-Sokkary
Mar 14, 2021·European Journal of Haematology·Stephanie E WeissingerPeter Möller
Jul 21, 2021·Life Science Alliance·Husen M UmerClaes Wadelius

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.